DegronMD

Uniprot ID: Q8IWU2

Source protein: Serine/threonine-protein kinase LMTK2

Source gene: LMTK2

Class: DEG_SCF_TRCP1_1

Location: 1029:1034

E3 ligase: BTRC

DEGRON score: 0.973

ASA_SCORE: 62.2

COIL: 0.708

CONS_SCORE: 0.3999

DSS_SCORE: 0.7442

HELIX: 0.1178

FCONS_SCORE: 1.0919

RIG_SCORE: 0.6199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1033K	TCGA-95-7947	LUAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	0.591
p.E1033K	DO26404	LUAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.591
p.D1025N	TCGA-AA-3489	COAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	0.2222
p.D1025N	DO10702	COAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.2222
p.E1041A	TCGA-B5-A1MX	UCEC	TCGA	DSGYET	DEG_SCF_TRCP1_1	0.1389
p.E1041A	DO41999	UCEC	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.1389
p.L1044S	TCGA-CK-4951	COAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	0.0556
p.L1044S	DO10582	COAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.0556
p.S1039F	TCGA-CK-6746	COAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	0.1944
p.S1039F	DO7938	COAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.1944
p.E1038K	TCGA-DU-6392	LGG	TCGA	DSGYET	DEG_SCF_TRCP1_1	0.2222
p.E1038K	DO22237	LGG	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.2222
p.L1021P	TCGA-VQ-A8PO	STAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	0.1111
p.L1021P	DO51773	STAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.1111
p.E1041K	DO233767	GACA	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.1389
p.E1041K	SIDM00499	Prostate Carcinoma	GDSC	DSGYET	DEG_SCF_TRCP1_1	0.1389
p.E1041K	ACH-000956	Prostate Cancer	CCLE	DSGYET	DEG_SCF_TRCP1_1	0.1389
p.E1041K	22RV1	prostate	COSMIC	DSGYET	DEG_SCF_TRCP1_1	0.1389
p.A1028S	DO229028	LICA	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.3056
p.P1040L	DO222363	MELA	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.1667
p.A1028T	SIDM00273	Glioblastoma	GDSC	DSGYET	DEG_SCF_TRCP1_1	0.3056
p.A1028T	ACH-000756	Brain Cancer	CCLE	DSGYET	DEG_SCF_TRCP1_1	0.3056
p.A1028T	GI-1	central_nervous_system	COSMIC	DSGYET	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWU2	Serine/threonine-protein kinase LMTK2	DEG_SCF_TRCP1_1	1029:1034	DSGYET	BTRC	0.973	More...
Q96Q04	Serine/threonine-protein kinase LMTK3	DEG_SCF_TRCP1_1	792:797	DSGYET	BTRC	0.984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons