DegronMD

Uniprot ID: Q8IWU2

Source protein: Serine/threonine-protein kinase LMTK2

Source gene: LMTK2

Class: DEG_SCF_FBW7_2

Location: 87:94

E3 ligase: FBXW7

DEGRON score: 0.8684

ASA_SCORE: 71.7375

COIL: 0.7801

CONS_SCORE: 0.4878

DSS_SCORE: 0.6679

HELIX: 0.172

FCONS_SCORE: 1.0686

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E86D	TCGA-A5-A0G2	UCEC	TCGA	IDFTPPAE	DEG_SCF_FBW7_2	0.3056
p.E86D	DO41235	UCEC	ICGC	IDFTPPAE	DEG_SCF_FBW7_2	0.3056
p.E86D	ACH-000975	Lung Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.3056
p.N82D	TCGA-AA-A010	COAD	TCGA	IDFTPPAE	DEG_SCF_FBW7_2	0.1944
p.N82D	DO231708	LINC	ICGC	IDFTPPAE	DEG_SCF_FBW7_2	0.1944
p.D88Y	TCGA-F5-6814	READ	TCGA	IDFTPPAE	DEG_SCF_FBW7_2	0.6214
p.D88Y	DO36556	READ	ICGC	IDFTPPAE	DEG_SCF_FBW7_2	0.6214
p.A103S	DO229026	LICA	ICGC	IDFTPPAE	DEG_SCF_FBW7_2	0.0833
p.T96P	SIDM00695	Melanoma	GDSC	IDFTPPAE	DEG_SCF_FBW7_2	0.2778
p.T96P	ACH-000322	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.2778
p.T96P	ACH-002458	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.2778
p.T96P	ACH-002459	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.2778
p.T96P	ACH-002460	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.2778
p.T96P	HT-144	skin	COSMIC	IDFTPPAE	DEG_SCF_FBW7_2	0.2778
p.P97L	SIDM01240	Melanoma	GDSC	IDFTPPAE	DEG_SCF_FBW7_2	0.25
p.P97L	ACH-001002	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.25
p.P97L	451Lu	skin	COSMIC	IDFTPPAE	DEG_SCF_FBW7_2	0.25
p.A93V	SIDM00217	Colorectal Carcinoma	GDSC	IDFTPPAE	DEG_SCF_FBW7_2	0.5825
p.A93V	ACH-000999	Colon/Colorectal Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.5825
p.A93V	SNU-1040	large_intestine	COSMIC	IDFTPPAE	DEG_SCF_FBW7_2	0.5825
p.P92R	ACH-001403	Ovarian Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.6401
p.P102S	ACH-001677	Lymphoma	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWU2	Serine/threonine-protein kinase LMTK2	DEG_SCF_FBW7_2	87:94	IDFTPPAE	FBXW7	0.8684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons