DegronMD

Uniprot ID: O43312

Source protein: Protein MTSS 1

Source gene: MTSS1

Class: DEG_SCF_TRCP1_1

Location: 321:326

E3 ligase: BTRC

DEGRON score: 0.9966

ASA_SCORE: 69.5

COIL: 0.8528

CONS_SCORE: 0.4185

DSS_SCORE: 0.5302

HELIX: 0.1057

FCONS_SCORE: 0.8608

RIG_SCORE: 0.6335

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R313T	TCGA-61-2095	OV	TCGA	DSGFIS	DEG_SCF_TRCP1_1	0.1111
p.A329V	TCGA-EO-A22T	UCEC	TCGA	DSGFIS	DEG_SCF_TRCP1_1	0.25
p.G320A	DO474	BLCA	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.3056
p.P328L	DO224938	BRCA	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.2778
p.G320R	DO8224	COAD	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.3056
p.G320E	DO37406	SKCM	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.3056
p.P328T	DO47873	STAD	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.2778
p.R318C	DO47833	STAD	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.6944
p.R318C	DO43779	UCEC	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.6944
p.V333M	DO223286	UCEC	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.25
p.P332H	DO42568	UCEC	ICGC	DSGFIS	DEG_SCF_TRCP1_1	0.1667
p.E321Q	OACM5-1	oesophagus	COSMIC	DSGFIS	DEG_SCF_TRCP1_1	0.6744
p.P315A	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFIS	DEG_SCF_TRCP1_1	0.1667
p.R318H	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFIS	DEG_SCF_TRCP1_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43312	Protein MTSS 1	DEG_SCF_TRCP1_1	321:326	DSGFIS	BTRC	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons