DegronMD - O43312(MTSS1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G728E	TCGA-55-7727	LUAD	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation altering degron motif	0.6087
p.R381W	TCGA-60-2726	LUSC	TCGA	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.1111
p.R381W	DO27484	LUSC	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.1111
p.R313T	TCGA-61-2095	OV	TCGA	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.1111
p.S704N	TCGA-85-8048	LUSC	TCGA	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.5958
p.S715N	TCGA-AA-3679	COAD	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.1389
p.S715N	TCGA-AA-3679	COAD	TCGA	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.1944
p.P726Q	TCGA-AP-A1DP	UCEC	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation altering degron motif	0.7035
p.A705V	TCGA-BR-4184	STAD	TCGA	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.6936
p.R700W	TCGA-D3-A8GM	SKCM	TCGA	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.2778
p.V739A	TCGA-DI-A1BU	UCEC	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.0556
p.P380S	TCGA-EE-A3JA	SKCM	TCGA	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.0833
p.P380S	DO47625	SKCM	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.0833
p.A329V	TCGA-EO-A22T	UCEC	TCGA	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.25
p.A734T	TCGA-FI-A2D5	UCEC	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.1944
p.Q711R	TCGA-FP-7829	STAD	TCGA	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.3056
p.P396Q	DO49802	BLCA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7035
p.G320A	DO474	BLCA	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.3056
p.P328L	DO224938	BRCA	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.2778
p.G320R	DO8224	COAD	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.3056
p.G395D	DO227987	COCA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7198
p.G399A	DO233751	GACA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.3056
p.P402Q	DO233855	GACA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.2222
p.D389E	DO228948	LICA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.6758
p.I406M	DO228981	LICA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.1111
p.P398T	DO229022	LICA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7031
p.M382I	DO50871	LICA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.1389
p.P380L	DO222843	MELA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.0833
p.M382K	DO34448	PACA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.1389
p.Y390F	DO34905	PACA	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7528
p.G385S	DO51078	PRAD	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.2222
p.G320E	DO37406	SKCM	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.3056
p.I408N	DO38404	STAD	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.0556
p.P328T	DO47873	STAD	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.2778
p.R318C	DO47833	STAD	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation blocking phosphorylation signal	0.6944
p.R318C	DO43779	UCEC	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation blocking phosphorylation signal	0.6944
p.G385D	DO38332	STAD	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.2222
p.S384R	DO42023	UCEC	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.1944
p.V333M	DO223286	UCEC	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation substituting flanking lysine	0.25
p.P332H	DO42568	UCEC	ICGC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.1667
p.K397R	DO41235	UCEC	ICGC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7237
p.E698A	SIDM00305	Ovarian Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.2222
p.Q715P	SIDM00845	Burkitt's Lymphoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.1389
p.Q715P	SIDM00845	Burkitt's Lymphoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.1944
p.Q715P	SIDM01519	Head and Neck Carcinoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.1389
p.Q715P	SIDM01519	Head and Neck Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.1944
p.P707Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.7035
p.P707Q	SIDM00032	Bladder Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.7035
p.P707Q	SIDM00479	Esophageal Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.7035
p.G714D	SIDM00789	Colorectal Carcinoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.1111
p.G714D	SIDM00789	Colorectal Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.2222
p.G714D	HCT-15	large intestine	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.1111
p.G714D	HCT-15	large intestine	COSMIC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.2222
p.A395T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7139
p.A395T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7139
p.S712F	SIDM00695	Melanoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.0556
p.S712F	SIDM00695	Melanoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.2778
p.S712F	HT-144	skin	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.0556
p.S712F	HT-144	skin	COSMIC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.2778
p.R727K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation altering degron motif	0.7237
p.R727K	NCI-H1155	lung	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation altering degron motif	0.7237
p.S712Y	SIDM01753	Gastric Carcinoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation rewiring degron network	0.0556
p.S712Y	SIDM01753	Gastric Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.2778
p.E694A	ACH-000132	Ovarian Cancer	CCLE	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.1111
p.S708F	ACH-000322	Skin Cancer	CCLE	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.6871
p.S708F	HT-144	skin	COSMIC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.6871
p.R723K	ACH-000980	Lung Cancer	CCLE	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation altering degron motif	0.6126
p.R723K	NCI-H1155	lung	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation altering degron motif	0.6126
p.G710D	ACH-000997	Colon/Colorectal Cancer	CCLE	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.6087
p.G710D	HCT-15	large intestine	COSMIC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation altering degron motif	0.6087
p.T395P	ACH-002162	Skin Cancer	CCLE	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7031
p.T395P	MMAC-SF	skin	COSMIC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7031
p.A391T	ACH-002256	Leukemia	CCLE	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.6028
p.A391T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.6028
p.P396L	DU-145	prostate	COSMIC	DYAHYYTIGP	CBL_PTK	389:398	Mutation altering degron motif	0.7582
p.E321Q	OACM5-1	oesophagus	COSMIC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation altering degron motif	0.6744
p.R698K	NCI-H1155	lung	COSMIC	PPSATVSPG	DEG_SIAH_1	702:710	Mutation rewiring degron network	0.2222
p.R724C	CP50-MEL-B	skin	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	722:729	Mutation altering degron motif	0.8301
p.R403H	BALL-1	haematopoietic and lymphoid tissue	COSMIC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.1944
p.E406Q	OACM5-1	oesophagus	COSMIC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.1111
p.P315A	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation rewiring degron network	0.1667
p.R318H	BALL-1	haematopoietic and lymphoid tissue	COSMIC	DSGFIS	DEG_SCF_TRCP1_1	321:326	Mutation blocking phosphorylation signal	0.6944
p.T399P	MMAC-SF	skin	COSMIC	DYAHYYTIGP	CBL_PTK	389:398	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTSS1

UniProt ID: O43312

Entrez ID: 9788

Protein name: Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MTSS1 in