DegronMD

Uniprot ID: O43312

Source protein: Protein MTSS 1

Source gene: MTSS1

Class: CBL_PTK

Location: 389:398

E3 ligase: CBL

DEGRON score: 0.5074

ASA_SCORE: 68.98

COIL: 0.7736

CONS_SCORE: 0.3378

DSS_SCORE: 0.1512

HELIX: 0.0943

FCONS_SCORE: 0.8358

RIG_SCORE: 0.814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R381W	TCGA-60-2726	LUSC	TCGA	DYAHYYTIGP	CBL_PTK	0.1111
p.R381W	DO27484	LUSC	ICGC	DYAHYYTIGP	CBL_PTK	0.1111
p.P380S	TCGA-EE-A3JA	SKCM	TCGA	DYAHYYTIGP	CBL_PTK	0.0833
p.P380S	DO47625	SKCM	ICGC	DYAHYYTIGP	CBL_PTK	0.0833
p.P396Q	DO49802	BLCA	ICGC	DYAHYYTIGP	CBL_PTK	0.7035
p.G395D	DO227987	COCA	ICGC	DYAHYYTIGP	CBL_PTK	0.7198
p.G399A	DO233751	GACA	ICGC	DYAHYYTIGP	CBL_PTK	0.3056
p.P402Q	DO233855	GACA	ICGC	DYAHYYTIGP	CBL_PTK	0.2222
p.D389E	DO228948	LICA	ICGC	DYAHYYTIGP	CBL_PTK	0.6758
p.I406M	DO228981	LICA	ICGC	DYAHYYTIGP	CBL_PTK	0.1111
p.P398T	DO229022	LICA	ICGC	DYAHYYTIGP	CBL_PTK	0.7031
p.M382I	DO50871	LICA	ICGC	DYAHYYTIGP	CBL_PTK	0.1389
p.P380L	DO222843	MELA	ICGC	DYAHYYTIGP	CBL_PTK	0.0833
p.M382K	DO34448	PACA	ICGC	DYAHYYTIGP	CBL_PTK	0.1389
p.Y390F	DO34905	PACA	ICGC	DYAHYYTIGP	CBL_PTK	0.7528
p.G385S	DO51078	PRAD	ICGC	DYAHYYTIGP	CBL_PTK	0.2222
p.I408N	DO38404	STAD	ICGC	DYAHYYTIGP	CBL_PTK	0.0556
p.G385D	DO38332	STAD	ICGC	DYAHYYTIGP	CBL_PTK	0.2222
p.S384R	DO42023	UCEC	ICGC	DYAHYYTIGP	CBL_PTK	0.1944
p.K397R	DO41235	UCEC	ICGC	DYAHYYTIGP	CBL_PTK	0.7237
p.A395T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DYAHYYTIGP	CBL_PTK	0.7139
p.A395T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DYAHYYTIGP	CBL_PTK	0.7139
p.T395P	ACH-002162	Skin Cancer	CCLE	DYAHYYTIGP	CBL_PTK	0.7031
p.T395P	MMAC-SF	skin	COSMIC	DYAHYYTIGP	CBL_PTK	0.7031
p.A391T	ACH-002256	Leukemia	CCLE	DYAHYYTIGP	CBL_PTK	0.6028
p.A391T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DYAHYYTIGP	CBL_PTK	0.6028
p.P396L	DU-145	prostate	COSMIC	DYAHYYTIGP	CBL_PTK	0.7582
p.R403H	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DYAHYYTIGP	CBL_PTK	0.1944
p.E406Q	OACM5-1	oesophagus	COSMIC	DYAHYYTIGP	CBL_PTK	0.1111
p.T399P	MMAC-SF	skin	COSMIC	DYAHYYTIGP	CBL_PTK	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43312	Protein MTSS 1	CBL_PTK	389:398	DYAHYYTIGP	CBL	0.5074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DYAHYYTIGP

Degron related mutations and impact score

Drug responses associated with MTSS1 mutations

All proteins holding degron of DYAHYYTIGP