DegronMD

Uniprot ID: O43312

Source protein: Protein MTSS 1

Source gene: MTSS1

Class: DEG_SCF_FBW7_2

Location: 722:729

E3 ligase: FBXW7

DEGRON score: 0.658

ASA_SCORE: 95.175

COIL: 0.9155

CONS_SCORE: 0.3679

DSS_SCORE: 0.7819

HELIX: 0.0569

FCONS_SCORE: 0.8545

RIG_SCORE: 0.6318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G728E	TCGA-55-7727	LUAD	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	0.6087
p.S715N	TCGA-AA-3679	COAD	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	0.1389
p.P726Q	TCGA-AP-A1DP	UCEC	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	0.7035
p.V739A	TCGA-DI-A1BU	UCEC	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	0.0556
p.A734T	TCGA-FI-A2D5	UCEC	TCGA	PRDTPQGE	DEG_SCF_FBW7_2	0.1944
p.Q715P	SIDM00845	Burkitt's Lymphoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	0.1389
p.Q715P	SIDM01519	Head and Neck Carcinoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	0.1389
p.G714D	SIDM00789	Colorectal Carcinoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	0.1111
p.G714D	HCT-15	large_intestine	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	0.1111
p.S712F	SIDM00695	Melanoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	0.0556
p.S712F	HT-144	skin	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	0.0556
p.R727K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	0.7237
p.R727K	NCI-H1155	lung	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	0.7237
p.S712Y	SIDM01753	Gastric Carcinoma	GDSC	PRDTPQGE	DEG_SCF_FBW7_2	0.0556
p.R723K	ACH-000980	Lung Cancer	CCLE	PRDTPQGE	DEG_SCF_FBW7_2	0.6126
p.R723K	NCI-H1155	lung	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	0.6126
p.R724C	CP50-MEL-B	skin	COSMIC	PRDTPQGE	DEG_SCF_FBW7_2	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43312	Protein MTSS 1	DEG_SCF_FBW7_2	722:729	PRDTPQGE	FBXW7	0.658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons