DegronMD

Uniprot ID: O43312

Source protein: Protein MTSS 1

Source gene: MTSS1

Class: DEG_SIAH_1

Location: 702:710

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9916

ASA_SCORE: 78.5667

COIL: 0.9538

CONS_SCORE: 0.3316

DSS_SCORE: 0.9185

HELIX: 0.0261

FCONS_SCORE: 0.9762

RIG_SCORE: 0.531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S704N	TCGA-85-8048	LUSC	TCGA	PPSATVSPG	DEG_SIAH_1	0.5958
p.S715N	TCGA-AA-3679	COAD	TCGA	PPSATVSPG	DEG_SIAH_1	0.1944
p.A705V	TCGA-BR-4184	STAD	TCGA	PPSATVSPG	DEG_SIAH_1	0.6936
p.R700W	TCGA-D3-A8GM	SKCM	TCGA	PPSATVSPG	DEG_SIAH_1	0.2778
p.Q711R	TCGA-FP-7829	STAD	TCGA	PPSATVSPG	DEG_SIAH_1	0.3056
p.E698A	SIDM00305	Ovarian Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.2222
p.Q715P	SIDM00845	Burkitt's Lymphoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.1944
p.Q715P	SIDM01519	Head and Neck Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.1944
p.P707Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.7035
p.P707Q	SIDM00032	Bladder Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.7035
p.P707Q	SIDM00479	Esophageal Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.7035
p.G714D	SIDM00789	Colorectal Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.2222
p.G714D	HCT-15	large_intestine	COSMIC	PPSATVSPG	DEG_SIAH_1	0.2222
p.S712F	SIDM00695	Melanoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.2778
p.S712F	HT-144	skin	COSMIC	PPSATVSPG	DEG_SIAH_1	0.2778
p.S712Y	SIDM01753	Gastric Carcinoma	GDSC	PPSATVSPG	DEG_SIAH_1	0.2778
p.E694A	ACH-000132	Ovarian Cancer	CCLE	PPSATVSPG	DEG_SIAH_1	0.1111
p.S708F	ACH-000322	Skin Cancer	CCLE	PPSATVSPG	DEG_SIAH_1	0.6871
p.S708F	HT-144	skin	COSMIC	PPSATVSPG	DEG_SIAH_1	0.6871
p.G710D	ACH-000997	Colon/Colorectal Cancer	CCLE	PPSATVSPG	DEG_SIAH_1	0.6087
p.G710D	HCT-15	large_intestine	COSMIC	PPSATVSPG	DEG_SIAH_1	0.6087
p.R698K	NCI-H1155	lung	COSMIC	PPSATVSPG	DEG_SIAH_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43312	Protein MTSS 1	DEG_SIAH_1	702:710	PPSATVSPG	SIAH1,SIAH2,SIAH3	0.9916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons