DegronMD

Uniprot ID: Q86V87

Source protein: FHF complex subunit HOOK interacting protein 2B

Source gene: FHIP2B

Class: DEG_SCF_TRCP1_1

Location: 510:515

E3 ligase: BTRC

DEGRON score: 0.9944

ASA_SCORE: 66.35

COIL: 0.8348

CONS_SCORE: 0.3309

DSS_SCORE: 0.4646

HELIX: 0.1037

FCONS_SCORE: 0.9863

RIG_SCORE: 0.729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S507I	TCGA-AP-A051	UCEC	TCGA	DSGFQT	DEG_SCF_TRCP1_1	0.25
p.S507I	DO42673	UCEC	ICGC	DSGFQT	DEG_SCF_TRCP1_1	0.25
p.D510N	TCGA-CQ-6221	HNSC	TCGA	DSGFQT	DEG_SCF_TRCP1_1	0.6932
p.D510N	DO14622	HNSC	ICGC	DSGFQT	DEG_SCF_TRCP1_1	0.6932
p.F513L	TCGA-WS-AB45	COAD	TCGA	DSGFQT	DEG_SCF_TRCP1_1	0.587
p.F513L	DO51734	COAD	ICGC	DSGFQT	DEG_SCF_TRCP1_1	0.587
p.S507R	DO48388	BLCA	ICGC	DSGFQT	DEG_SCF_TRCP1_1	0.25
p.A517T	DO234387	ESAD	ICGC	DSGFQT	DEG_SCF_TRCP1_1	0.2778
p.Y503N	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGFQT	DEG_SCF_TRCP1_1	0.1389
p.Y503N	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFQT	DEG_SCF_TRCP1_1	0.1389
p.Y503C	SIDM01779	Gastric Carcinoma	GDSC	DSGFQT	DEG_SCF_TRCP1_1	0.1389
p.Y503C	ACH-000761	Gastric Cancer	CCLE	DSGFQT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86V87	FHF complex subunit HOOK interacting protein 2B	DEG_SCF_TRCP1_1	510:515	DSGFQT	BTRC	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons