DegronMD

Uniprot ID: Q9NYL2

Source protein: Mitogen-activated protein kinase kinase kinase 20

Source gene: MAP3K20

Class: DEG_SCF_TRCP1_1

Location: 656:661

E3 ligase: BTRC

DEGRON score: 0.9991

ASA_SCORE: 66.8667

COIL: 0.9338

CONS_SCORE: 0.4476

DSS_SCORE: 0.5667

HELIX: 0.0345

FCONS_SCORE: 1.2223

RIG_SCORE: 0.5794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H651R	SIDM00961	Ewing's Sarcoma	GDSC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.H651R	SIDM00397	Acute Myeloid Leukemia	GDSC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.H651R	SIDM00560	Gastric Carcinoma	GDSC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.H651R	SIDM00603	Head and Neck Carcinoma	GDSC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.H651R	SIDM01454	Kidney Carcinoma	GDSC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.H651R	MKN7	stomach	COSMIC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.H651R	KOSC-2	upper_aerodigestive_tract	COSMIC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.H651R	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.H651R	CADO-ES1	bone	COSMIC	DSGFSS	DEG_SCF_TRCP1_1	0.1944
p.S649F	SIDM01175	Other Sarcomas	GDSC	DSGFSS	DEG_SCF_TRCP1_1	0.5833
p.S649F	SW684	soft_tissue	COSMIC	DSGFSS	DEG_SCF_TRCP1_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07333	Macrophage colony-stimulating factor 1 receptor	DEG_SCF_TRCP1_1	712:717	DSGFSS	BTRC	0.9992	More...
Q9NYL2	Mitogen-activated protein kinase kinase kinase 20	DEG_SCF_TRCP1_1	656:661	DSGFSS	BTRC	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons