MAP3K20
UniProt ID: Q9NYL2
Entrez ID: 51776
Protein name: Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2...
FUNCTION: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). {ECO:0000269|PubMed:10924358, ECO:0000269|PubMed:11836244, ECO:0000269|PubMed:15342622, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:26755636}.; FUNCTION: [Isoform 1]: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189). {ECO:0000269|PubMed:11042189, ECO:0000269|PubMed:15172994, ECO:0000269|PubMed:15684425}.
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GO - Biological processes (BP):
cell cycle [GO:0007049]; cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint signaling [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; JNK cascade [GO:0007254]; limb dev...
cell cycle [GO:0007049]; cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint signaling [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; JNK cascade [GO:0007254]; limb development [GO:0060173]; p38MAPK cascade [GO:0038066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of mitotic DNA damage checkpoint [GO:1904291]; protein phosphorylation [GO:0006468]; stress-activated MAPK cascade [GO:0051403]
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GO - Molecular function (MF):
ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein serine kinase activity [GO:0106310]; RNA binding [GO:0003723]...
ATP binding [GO:0005524]; JUN kinase kinase kinase activity [GO:0004706]; magnesium ion binding [GO:0000287]; MAP kinase kinase kinase activity [GO:0004709]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein serine kinase activity [GO:0106310]; RNA binding [GO:0003723]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]
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MAP3K20
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Kaplan plot for MAP3K20 in
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*NOTE: the Kaplan plots were collected from OncoLnc