DegronMD

Uniprot ID: Q9NYL2

Source protein: Mitogen-activated protein kinase kinase kinase 20

Source gene: MAP3K20

Class: LIG_APCC_ABBA_1

Location: 746:751

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9141

ASA_SCORE: 93.1333

COIL: 0.9087

CONS_SCORE: 0.3267

DSS_SCORE: 0.7778

HELIX: 0.0528

FCONS_SCORE: 1.009

RIG_SCORE: 0.6086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T752I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MPLHPE	LIG_APCC_ABBA_1	0.3056
p.T752I	SIDM01263	T-Lymphoblastic Leukemia	GDSC	MPLHPE	LIG_APCC_ABBA_1	0.3056
p.T752I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MPLHPE	LIG_APCC_ABBA_1	0.3056
p.G745E	SIDM00844	Burkitt's Lymphoma	GDSC	MPLHPE	LIG_APCC_ABBA_1	0.3056
p.G745E	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	MPLHPE	LIG_APCC_ABBA_1	0.3056
p.Q739H	SIDM01471	Chronic Myelogenous Leukemia	GDSC	MPLHPE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYL2	Mitogen-activated protein kinase kinase kinase 20	LIG_APCC_ABBA_1	746:751	MPLHPE	APC,CDC20,FZR1	0.9141	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons