DegronMD

Uniprot ID: Q9BUD6

Source protein: Spondin-2

Source gene: SPON2

Class: DEG_SCF_TRCP1_1

Location: 192:198

E3 ligase: BTRC

DEGRON score: 0.9695

ASA_SCORE: 58.7429

COIL: 0.7756

CONS_SCORE: 0.792

DSS_SCORE: 0.3515

HELIX: 0.0604

FCONS_SCORE: 1.1474

RIG_SCORE: 0.7211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S193C	DO229211	THCA	ICGC	DSGFTFS	DEG_SCF_TRCP1_1	0.7541
p.G194A	ACH-000822	Skin Cancer	CCLE	DSGFTFS	DEG_SCF_TRCP1_1	0.754
p.P206Q	ACH-000942	Leukemia	CCLE	DSGFTFS	DEG_SCF_TRCP1_1	0.1111
p.D188E	ACH-000945	Lung Cancer	CCLE	DSGFTFS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUD6	Spondin-2	DEG_SCF_TRCP1_1	192:198	DSGFTFS	BTRC	0.9695	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons