DegronMD - Q9BUD6(SPON2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S268R	TCGA-14-1794	GBM	TCGA	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.1111
p.S268R	DO13024	GBM	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.1111
p.F251Y	TCGA-B5-A3FC	UCEC	TCGA	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.3056
p.F251Y	DO41871	UCEC	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.3056
p.R243W	TCGA-BR-8680	STAD	TCGA	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.R243W	DO47769	STAD	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.A269T	TCGA-D7-8576	STAD	TCGA	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.A269T	TCGA-DU-6392	LGG	TCGA	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.A269T	DO22237	LGG	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.A269T	DO47977	STAD	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.S260N	TCGA-DM-A1HB	COAD	TCGA	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7069
p.S260N	DO233898	GACA	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7069
p.S260N	SIDM00846	Cervical Carcinoma	GDSC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7069
p.S260N	ACH-001086	Cervical Cancer	CCLE	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7069
p.S260N	HeLa	cervix	COSMIC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7069
p.Q246H	TCGA-HE-A5NL	KIRP	TCGA	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.1667
p.Q246H	DO44528	KIRP	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.1667
p.Q246E	TCGA-RD-A7C1	STAD	TCGA	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.1667
p.Q246E	DO50132	STAD	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.1667
p.V242L	DO229010	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0556
p.V242L	DO229013	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0556
p.V242L	DO229016	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0556
p.V242L	DO229003	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0556
p.V242L	DO229005	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0556
p.P253L	DO231165	LUSC	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7582
p.D262N	DO222595	MELA	ICGC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.2778
p.S193C	DO229211	THCA	ICGC	DSGFTFS	DEG_SCF_TRCP1_1	192:198	Mutation altering degron motif	0.7541
p.A269V	SIDM00499	Prostate Carcinoma	GDSC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.A269V	ACH-000956	Prostate Cancer	CCLE	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.A269V	22RV1	prostate	COSMIC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation rewiring degron network	0.0833
p.A255S	SIDM00273	Glioblastoma	GDSC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7588
p.A255S	ACH-000756	Brain Cancer	CCLE	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7588
p.A255S	GI-1	central nervous system	COSMIC	IPPAPVLPS	DEG_SIAH_1	252:260	Mutation altering degron motif	0.7588
p.G194A	ACH-000822	Skin Cancer	CCLE	DSGFTFS	DEG_SCF_TRCP1_1	192:198	Mutation altering degron motif	0.754
p.P206Q	ACH-000942	Leukemia	CCLE	DSGFTFS	DEG_SCF_TRCP1_1	192:198	Mutation rewiring degron network	0.1111
p.D188E	ACH-000945	Lung Cancer	CCLE	DSGFTFS	DEG_SCF_TRCP1_1	192:198	Mutation rewiring degron network	0.2222

Kaplan plot for SPON2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPON2

UniProt ID: Q9BUD6

Entrez ID: 10417

Protein name: Spondin-2 (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1) (Mindin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPON2 in