DegronMD

Uniprot ID: Q9BUD6

Source protein: Spondin-2

Source gene: SPON2

Class: DEG_SIAH_1

Location: 252:260

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9862

ASA_SCORE: 57.3

COIL: 0.8677

CONS_SCORE: 0.4576

DSS_SCORE: 0.3801

HELIX: 0.0262

FCONS_SCORE: 0.9914

RIG_SCORE: 0.7033

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S268R	TCGA-14-1794	GBM	TCGA	IPPAPVLPS	DEG_SIAH_1	0.1111
p.S268R	DO13024	GBM	ICGC	IPPAPVLPS	DEG_SIAH_1	0.1111
p.F251Y	TCGA-B5-A3FC	UCEC	TCGA	IPPAPVLPS	DEG_SIAH_1	0.3056
p.F251Y	DO41871	UCEC	ICGC	IPPAPVLPS	DEG_SIAH_1	0.3056
p.R243W	TCGA-BR-8680	STAD	TCGA	IPPAPVLPS	DEG_SIAH_1	0.0833
p.R243W	DO47769	STAD	ICGC	IPPAPVLPS	DEG_SIAH_1	0.0833
p.A269T	TCGA-D7-8576	STAD	TCGA	IPPAPVLPS	DEG_SIAH_1	0.0833
p.A269T	TCGA-DU-6392	LGG	TCGA	IPPAPVLPS	DEG_SIAH_1	0.0833
p.A269T	DO22237	LGG	ICGC	IPPAPVLPS	DEG_SIAH_1	0.0833
p.A269T	DO47977	STAD	ICGC	IPPAPVLPS	DEG_SIAH_1	0.0833
p.S260N	TCGA-DM-A1HB	COAD	TCGA	IPPAPVLPS	DEG_SIAH_1	0.7069
p.S260N	DO233898	GACA	ICGC	IPPAPVLPS	DEG_SIAH_1	0.7069
p.S260N	SIDM00846	Cervical Carcinoma	GDSC	IPPAPVLPS	DEG_SIAH_1	0.7069
p.S260N	ACH-001086	Cervical Cancer	CCLE	IPPAPVLPS	DEG_SIAH_1	0.7069
p.S260N	HeLa	cervix	COSMIC	IPPAPVLPS	DEG_SIAH_1	0.7069
p.Q246H	TCGA-HE-A5NL	KIRP	TCGA	IPPAPVLPS	DEG_SIAH_1	0.1667
p.Q246H	DO44528	KIRP	ICGC	IPPAPVLPS	DEG_SIAH_1	0.1667
p.Q246E	TCGA-RD-A7C1	STAD	TCGA	IPPAPVLPS	DEG_SIAH_1	0.1667
p.Q246E	DO50132	STAD	ICGC	IPPAPVLPS	DEG_SIAH_1	0.1667
p.V242L	DO229010	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	0.0556
p.V242L	DO229013	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	0.0556
p.V242L	DO229016	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	0.0556
p.V242L	DO229003	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	0.0556
p.V242L	DO229005	COCA	ICGC	IPPAPVLPS	DEG_SIAH_1	0.0556
p.P253L	DO231165	LUSC	ICGC	IPPAPVLPS	DEG_SIAH_1	0.7582
p.D262N	DO222595	MELA	ICGC	IPPAPVLPS	DEG_SIAH_1	0.2778
p.A269V	SIDM00499	Prostate Carcinoma	GDSC	IPPAPVLPS	DEG_SIAH_1	0.0833
p.A269V	ACH-000956	Prostate Cancer	CCLE	IPPAPVLPS	DEG_SIAH_1	0.0833
p.A269V	22RV1	prostate	COSMIC	IPPAPVLPS	DEG_SIAH_1	0.0833
p.A255S	SIDM00273	Glioblastoma	GDSC	IPPAPVLPS	DEG_SIAH_1	0.7588
p.A255S	ACH-000756	Brain Cancer	CCLE	IPPAPVLPS	DEG_SIAH_1	0.7588
p.A255S	GI-1	central_nervous_system	COSMIC	IPPAPVLPS	DEG_SIAH_1	0.7588

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPPAPVLPS

Degron related mutations and impact score

Drug responses associated with SPON2 mutations

All proteins holding degron of IPPAPVLPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUD6	Spondin-2	DEG_SIAH_1	252:260	IPPAPVLPS	SIAH1,SIAH2,SIAH3	0.9862	More...