DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_SCF_TRCP1_1

Location: 1859:1864

E3 ligase: BTRC

DEGRON score: 0.9822

ASA_SCORE: 82

COIL: 0.949

CONS_SCORE: 0.4381

DSS_SCORE: 0.6256

HELIX: 0.0212

FCONS_SCORE: 0.949

RIG_SCORE: 0.5542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1865S	DO229456	SKCA	ICGC	DSGGKT	DEG_SCF_TRCP1_1	0.3056
p.P1865L	DO229456	SKCA	ICGC	DSGGKT	DEG_SCF_TRCP1_1	0.3056
p.K1874N	SIDM00806	Osteosarcoma	GDSC	DSGGKT	DEG_SCF_TRCP1_1	0.5
p.K1874N	ACH-000613	Bone Cancer	CCLE	DSGGKT	DEG_SCF_TRCP1_1	0.5
p.K1874N	ACH-001001	Bone Cancer	CCLE	DSGGKT	DEG_SCF_TRCP1_1	0.5
p.K1874N	HOS	bone	COSMIC	DSGGKT	DEG_SCF_TRCP1_1	0.5
p.S1860N	SIDM00487	Colorectal Carcinoma	GDSC	DSGGKT	DEG_SCF_TRCP1_1	0.7069
p.S1860N	ACH-000963	Colon/Colorectal Cancer	CCLE	DSGGKT	DEG_SCF_TRCP1_1	0.7069
p.S1860N	CCK-81	large_intestine	COSMIC	DSGGKT	DEG_SCF_TRCP1_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SCF_TRCP1_1	1859:1864	DSGGKT	BTRC	0.9822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons