DegronMD

Uniprot ID: Q9NSC2

Source protein: Sal-like protein 1

Source gene: SALL1

Class: DEG_SCF_TRCP1_1

Location: 594:600

E3 ligase: BTRC

DEGRON score: 0.9942

ASA_SCORE: 61.7429

COIL: 0.8691

CONS_SCORE: 0.3684

DSS_SCORE: 0.7464

HELIX: 0.0656

FCONS_SCORE: 1.0025

RIG_SCORE: 0.5071

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P598H	TCGA-35-5375	LUAD	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.6583
p.P598H	TCGA-ER-A19B	SKCM	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.6583
p.P598H	DO25290	LUAD	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.6583
p.P598H	DO47491	SKCM	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.6583
p.P598H	SIDM00845	Burkitt's Lymphoma	GDSC	DSGGPES	DEG_SCF_TRCP1_1	0.6583
p.P598H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGPES	DEG_SCF_TRCP1_1	0.6583
p.N604S	TCGA-CG-5721	STAD	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.2222
p.N604S	DO38192	STAD	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.2222
p.R603K	TCGA-D3-A8GI	SKCM	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.25
p.R603K	TCGA-DA-A1IC	SKCM	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.25
p.R603K	DO220872	MELA	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.25
p.R603K	DO37430	SKCM	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.25
p.R603K	DO50284	SKCM	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.25
p.S590L	TCGA-D3-A8GL	SKCM	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.6667
p.S590L	DO50287	SKCM	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.6667
p.S590P	TCGA-D7-6818	STAD	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.6667
p.S590P	DO38262	STAD	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.6667
p.G596W	TCGA-D9-A148	SKCM	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.7825
p.G596W	DO37971	SKCM	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.7825
p.P587L	TCGA-EB-A431	SKCM	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.1389
p.P587L	DO37671	SKCM	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.1389
p.P609S	TCGA-EE-A29E	SKCM	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.0833
p.P609S	DO37831	SKCM	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.0833
p.G589S	TCGA-EE-A3JD	SKCM	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.1944
p.G589S	DO50299	SKCM	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.1944
p.E599K	TCGA-FJ-A3Z7	BLCA	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.591
p.E599K	DO463	BLCA	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.591
p.G589D	TCGA-IN-A6RN	STAD	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.1944
p.G589D	DO51739	STAD	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.1944
p.R603G	TCGA-NC-A5HN	LUSC	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.25
p.R603G	DO52025	LUSC	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.25
p.P587H	TCGA-VQ-A8P2	STAD	TCGA	DSGGPES	DEG_SCF_TRCP1_1	0.1389
p.P587H	DO51761	STAD	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.1389
p.A584S	DO50914	LICA	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.0556
p.T602K	DO230971	LUSC	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.2778
p.T602K	DO224630	LUSC	ICGC	DSGGPES	DEG_SCF_TRCP1_1	0.2778
p.S593G	SIDM01242	Melanoma	GDSC	DSGGPES	DEG_SCF_TRCP1_1	0.75
p.S593G	ACH-002162	Skin Cancer	CCLE	DSGGPES	DEG_SCF_TRCP1_1	0.75
p.S593G	MMAC-SF	skin	COSMIC	DSGGPES	DEG_SCF_TRCP1_1	0.75
p.P588S	SIDM00159	Biliary Tract Carcinoma	GDSC	DSGGPES	DEG_SCF_TRCP1_1	0.1667
p.A584T	ACH-000911	Gastric Cancer	CCLE	DSGGPES	DEG_SCF_TRCP1_1	0.0556
p.E590D	BICR10	upper_aerodigestive_tract	COSMIC	DSGGPES	DEG_SCF_TRCP1_1	0.6667
p.N600H	RL95-2	endometrium	COSMIC	DSGGPES	DEG_SCF_TRCP1_1	0.7423
p.L597M	SNU-175	large_intestine	COSMIC	DSGGPES	DEG_SCF_TRCP1_1	0.711
p.A586V	VM-CUB-1	urinary_tract	COSMIC	DSGGPES	DEG_SCF_TRCP1_1	0.5556
p.E590K	SNU-175	large_intestine	COSMIC	DSGGPES	DEG_SCF_TRCP1_1	0.6667
p.D602N	H513	pleura	COSMIC	DSGGPES	DEG_SCF_TRCP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGGPES

Degron related mutations and impact score

Drug responses associated with SALL1 mutations

All proteins holding degron of DSGGPES

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSC2	Sal-like protein 1	DEG_SCF_TRCP1_1	594:600	DSGGPES	BTRC	0.9942	More...