DegronMD

Uniprot ID: Q8NG08

Source protein: DNA helicase B

Source gene: HELB

Class: DEG_SCF_TRCP1_1

Location: 974:980

E3 ligase: BTRC

DEGRON score: 0.9955

ASA_SCORE: 81.2143

COIL: 0.9723

CONS_SCORE: 0.3233

DSS_SCORE: 0.7451

HELIX: 0.0087

FCONS_SCORE: 0.9949

RIG_SCORE: 0.4243

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S979I	TCGA-17-Z031	LUAD	TCGA	DSGGPST	DEG_SCF_TRCP1_1	0.7341
p.S979N	TCGA-A5-A0G2	UCEC	TCGA	DSGGPST	DEG_SCF_TRCP1_1	0.7069
p.S979N	DO41235	UCEC	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7069
p.T990I	TCGA-AP-A1DO	UCEC	TCGA	DSGGPST	DEG_SCF_TRCP1_1	0.0556
p.T990I	DO43250	UCEC	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.0556
p.P987L	TCGA-BF-AAOX	SKCM	TCGA	DSGGPST	DEG_SCF_TRCP1_1	0.1389
p.P987L	DO223907	SKCM	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1389
p.S975N	TCGA-BH-A18G	BRCA	TCGA	DSGGPST	DEG_SCF_TRCP1_1	0.7069
p.S975N	DO3686	BRCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7069
p.S967F	TCGA-CM-4743	COAD	TCGA	DSGGPST	DEG_SCF_TRCP1_1	0.5833
p.S967F	DO8103	COAD	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.5833
p.P966S	TCGA-D3-A5GN	SKCM	TCGA	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P966S	DO47317	SKCM	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P985A	DO52600	BOCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1944
p.T980I	DO230334	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7078
p.T980I	DO229010	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7078
p.T980I	DO229013	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7078
p.T980I	DO229005	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7078
p.T980I	DO234285	ESAD	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7078
p.T980I	DO229505	LAML	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7078
p.T980I	DO229047	LICA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7078
p.T980I	DO230993	LUSC	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.7078
p.P966L	DO230334	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P966L	DO227999	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P966L	DO229010	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P966L	DO229013	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P966L	DO229016	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P966L	DO229005	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P966L	DO229505	LAML	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111
p.P966L	DO228941	LICA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG08	DNA helicase B	DEG_SCF_TRCP1_1	974:980	DSGGPST	BTRC	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGGPST

Degron related mutations and impact score

Drug responses associated with HELB mutations

All proteins holding degron of DSGGPST