DegronMD - Q8NG08(HELB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S979I	TCGA-17-Z031	LUAD	TCGA	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.7341
p.S979I	TCGA-17-Z031	LUAD	TCGA	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7341
p.S979N	TCGA-A5-A0G2	UCEC	TCGA	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.7069
p.S979N	TCGA-A5-A0G2	UCEC	TCGA	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7069
p.S979N	DO41235	UCEC	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.7069
p.S979N	DO41235	UCEC	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7069
p.D991Y	TCGA-A5-A1OF	UCEC	TCGA	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.1389
p.D991Y	DO42568	UCEC	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.1389
p.T990I	TCGA-AP-A1DO	UCEC	TCGA	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.1667
p.T990I	TCGA-AP-A1DO	UCEC	TCGA	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.0556
p.T990I	DO43250	UCEC	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.1667
p.T990I	DO43250	UCEC	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.0556
p.P987L	TCGA-BF-AAOX	SKCM	TCGA	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.25
p.P987L	TCGA-BF-AAOX	SKCM	TCGA	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1389
p.P987L	DO223907	SKCM	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.25
p.P987L	DO223907	SKCM	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1389
p.S975N	TCGA-BH-A18G	BRCA	TCGA	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7069
p.S975N	DO3686	BRCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7069
p.S967F	TCGA-CM-4743	COAD	TCGA	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation blocking phosphorylation signal	0.5833
p.S967F	DO8103	COAD	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation blocking phosphorylation signal	0.5833
p.P966S	TCGA-D3-A5GN	SKCM	TCGA	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.P966S	DO47317	SKCM	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.A993V	TCGA-HU-A4GN	STAD	TCGA	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.0833
p.A993V	DO47833	STAD	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.0833
p.P985A	DO52600	BOCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation rewiring degron network	0.3056
p.P985A	DO52600	BOCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1944
p.T980I	DO230334	COCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.8189
p.T980I	DO230334	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7078
p.T980I	DO229010	COCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.8189
p.T980I	DO229010	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7078
p.T980I	DO229013	COCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.8189
p.T980I	DO229013	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7078
p.T980I	DO229005	COCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.8189
p.T980I	DO229005	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7078
p.T980I	DO234285	ESAD	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.8189
p.T980I	DO234285	ESAD	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7078
p.T980I	DO229505	LAML	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.8189
p.T980I	DO229505	LAML	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7078
p.T980I	DO229047	LICA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.8189
p.T980I	DO229047	LICA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7078
p.T980I	DO230993	LUSC	ICGC	PSTPSAS	DEG_SCF_FBW7_1	978:984	Mutation altering degron motif	0.8189
p.T980I	DO230993	LUSC	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation altering degron motif	0.7078
p.P966L	DO230334	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.P966L	DO227999	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.P966L	DO229010	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.P966L	DO229013	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.P966L	DO229016	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.P966L	DO229005	COCA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.P966L	DO229505	LAML	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111
p.P966L	DO228941	LICA	ICGC	DSGGPST	DEG_SCF_TRCP1_1	974:980	Mutation rewiring degron network	0.1111

Kaplan plot for HELB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HELB

UniProt ID: Q8NG08

Entrez ID: 92797

Protein name: DNA helicase B (hDHB) (EC 3.6.4.12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HELB in