DegronMD

Uniprot ID: Q8NG08

Source protein: DNA helicase B

Source gene: HELB

Class: DEG_SCF_FBW7_1

Location: 978:984

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 83.0429

COIL: 0.9601

CONS_SCORE: 0.415

DSS_SCORE: 0.7023

HELIX: 0.0136

FCONS_SCORE: 1.4028

RIG_SCORE: 0.5099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S979I	TCGA-17-Z031	LUAD	TCGA	PSTPSAS	DEG_SCF_FBW7_1	0.7341
p.S979N	TCGA-A5-A0G2	UCEC	TCGA	PSTPSAS	DEG_SCF_FBW7_1	0.7069
p.S979N	DO41235	UCEC	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.7069
p.D991Y	TCGA-A5-A1OF	UCEC	TCGA	PSTPSAS	DEG_SCF_FBW7_1	0.1389
p.D991Y	DO42568	UCEC	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.1389
p.T990I	TCGA-AP-A1DO	UCEC	TCGA	PSTPSAS	DEG_SCF_FBW7_1	0.1667
p.T990I	DO43250	UCEC	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.1667
p.P987L	TCGA-BF-AAOX	SKCM	TCGA	PSTPSAS	DEG_SCF_FBW7_1	0.25
p.P987L	DO223907	SKCM	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.25
p.A993V	TCGA-HU-A4GN	STAD	TCGA	PSTPSAS	DEG_SCF_FBW7_1	0.0833
p.A993V	DO47833	STAD	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.0833
p.P985A	DO52600	BOCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.3056
p.T980I	DO230334	COCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.8189
p.T980I	DO229010	COCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.8189
p.T980I	DO229013	COCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.8189
p.T980I	DO229005	COCA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.8189
p.T980I	DO234285	ESAD	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.8189
p.T980I	DO229505	LAML	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.8189
p.T980I	DO229047	LICA	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.8189
p.T980I	DO230993	LUSC	ICGC	PSTPSAS	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG08	DNA helicase B	DEG_SCF_FBW7_1	978:984	PSTPSAS	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons