DegronMD

Uniprot ID: P07332

Source protein: Tyrosine-protein kinase Fes/Fps

Source gene: FES

Class: DEG_SCF_TRCP1_1

Location: 55:60

E3 ligase: BTRC

DEGRON score: 0.9748

ASA_SCORE: 62.95

COIL: 0.8167

CONS_SCORE: 0.4092

DSS_SCORE: 0.5656

HELIX: 0.1445

FCONS_SCORE: 0.8998

RIG_SCORE: 0.5852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S60R	TCGA-AP-A051	UCEC	TCGA	DSGGQS	DEG_SCF_TRCP1_1	0.7427
p.S60R	DO42673	UCEC	ICGC	DSGGQS	DEG_SCF_TRCP1_1	0.7427
p.M51T	TCGA-DI-A1BU	UCEC	TCGA	DSGGQS	DEG_SCF_TRCP1_1	0.2222
p.M51T	DO42023	UCEC	ICGC	DSGGQS	DEG_SCF_TRCP1_1	0.2222
p.S67I	DO222454	BTCA	ICGC	DSGGQS	DEG_SCF_TRCP1_1	0.5833
p.A62T	DO234389	ESAD	ICGC	DSGGQS	DEG_SCF_TRCP1_1	0.2778
p.R61Q	SIDM00332	Breast Carcinoma	GDSC	DSGGQS	DEG_SCF_TRCP1_1	0.3056
p.R61Q	ACH-001819	Breast Cancer	CCLE	DSGGQS	DEG_SCF_TRCP1_1	0.3056
p.R61Q	MFM-223	breast	COSMIC	DSGGQS	DEG_SCF_TRCP1_1	0.3056
p.G58S	SIDM00618	Hepatocellular Carcinoma	GDSC	DSGGQS	DEG_SCF_TRCP1_1	0.5882
p.G58S	ACH-000620	Liver Cancer	CCLE	DSGGQS	DEG_SCF_TRCP1_1	0.5882
p.G58S	JHH-1	liver	COSMIC	DSGGQS	DEG_SCF_TRCP1_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07332	Tyrosine-protein kinase Fes/Fps	DEG_SCF_TRCP1_1	55:60	DSGGQS	BTRC	0.9748	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons