DegronMD

Uniprot ID: Q18PE1

Source protein: Protein Dok-7

Source gene: DOK7

Class: DEG_SCF_TRCP1_1

Location: 433:439

E3 ligase: BTRC

DEGRON score: 0.9931

ASA_SCORE: 73.5286

COIL: 0.85

CONS_SCORE: 0.4893

DSS_SCORE: 0.6837

HELIX: 0.0463

FCONS_SCORE: 1.0356

RIG_SCORE: 0.5454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S425G	TCGA-AA-3984	COAD	TCGA	DSGGQTS	DEG_SCF_TRCP1_1	0.5556
p.S425G	DO9002	COAD	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	0.5556
p.G436D	TCGA-BF-A5EO	SKCM	TCGA	DSGGQTS	DEG_SCF_TRCP1_1	0.6087
p.G436D	DO219450	SKCM	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	0.6087
p.G427S	TCGA-BR-8487	STAD	TCGA	DSGGQTS	DEG_SCF_TRCP1_1	0.1667
p.G427S	DO47867	STAD	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	0.1667
p.N428K	DO225048	BRCA	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	0.1944
p.T449M	DO233882	GACA	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	0.0556
p.A440T	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGQTS	DEG_SCF_TRCP1_1	0.3056
p.A440T	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGQTS	DEG_SCF_TRCP1_1	0.3056
p.G448S	SIDM01159	Other Sarcomas	GDSC	DSGGQTS	DEG_SCF_TRCP1_1	0.0833
p.G448S	ACH-002310	Liposarcoma	CCLE	DSGGQTS	DEG_SCF_TRCP1_1	0.0833
p.G448S	SW872	soft_tissue	COSMIC	DSGGQTS	DEG_SCF_TRCP1_1	0.0833
p.T438R	SIDM01368	Gastric Carcinoma	GDSC	DSGGQTS	DEG_SCF_TRCP1_1	0.6765
p.T438R	SIDM01619	Endometrial Carcinoma	GDSC	DSGGQTS	DEG_SCF_TRCP1_1	0.6765
p.G436R	786-0	kidney	COSMIC	DSGGQTS	DEG_SCF_TRCP1_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q18PE1	Protein Dok-7	DEG_SCF_TRCP1_1	433:439	DSGGQTS	BTRC	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons