DegronMD - Q18PE1(DOK7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S425G	TCGA-AA-3984	COAD	TCGA	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation blocking phosphorylation signal	0.5556
p.S425G	DO9002	COAD	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation blocking phosphorylation signal	0.5556
p.G436D	TCGA-BF-A5EO	SKCM	TCGA	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation altering degron motif	0.6087
p.G436D	DO219450	SKCM	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation altering degron motif	0.6087
p.G427S	TCGA-BR-8487	STAD	TCGA	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.1667
p.G427S	DO47867	STAD	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.1667
p.V40A	TCGA-G2-A2ES	BLCA	TCGA	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6936
p.V40A	DO785	BLCA	ICGC	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.6936
p.R52W	TCGA-VS-A9UH	CESC	TCGA	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.R52W	DO51642	CESC	ICGC	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.0833
p.N428K	DO225048	BRCA	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.1944
p.T449M	DO233882	GACA	ICGC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.0556
p.K42N	DO229022	LICA	ICGC	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation altering degron motif	0.5806
p.S349C	DO230993	LUSC	ICGC	DSGIAT	DEG_SCF_TRCP1_1	337:342	Mutation rewiring degron network	0.1389
p.L352H	SIDM01951	Colorectal Carcinoma	GDSC	DSGIAT	DEG_SCF_TRCP1_1	337:342	Mutation rewiring degron network	0.0556
p.A341T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGIAT	DEG_SCF_TRCP1_1	337:342	Mutation altering degron motif	0.6028
p.I48T	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.I48T	SIDM00054	Pancreatic Carcinoma	GDSC	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.I48T	ACH-000062	Lung Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.I48T	ACH-001619	Gallbladder Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.I48T	ACH-001850	Gallbladder Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.I48T	ACH-002185	Pancreatic Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.1944
p.E46K	SIDM00346	Chronic Myelogenous Leukemia	GDSC	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.25
p.E46K	ACH-000301	Leukemia	CCLE	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.25
p.E46K	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation rewiring degron network	0.25
p.A440T	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.3056
p.A440T	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.3056
p.G448S	SIDM01159	Other Sarcomas	GDSC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.0833
p.G448S	ACH-002310	Liposarcoma	CCLE	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.0833
p.G448S	SW872	soft tissue	COSMIC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.0833
p.T438R	SIDM01368	Gastric Carcinoma	GDSC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation altering degron motif	0.6765
p.T438R	SIDM01619	Endometrial Carcinoma	GDSC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation altering degron motif	0.6765
p.K49N	ACH-000637	Esophageal Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	38:43	Mutation substituting flanking lysine	0.2778
p.G436R	786-0	kidney	COSMIC	DSGGQTS	DEG_SCF_TRCP1_1	433:439	Mutation altering degron motif	0.6457
p.F344L	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	DSGIAT	DEG_SCF_TRCP1_1	337:342	Mutation rewiring degron network	0.2778
p.A333S	NCI-H650	lung	COSMIC	DSGIAT	DEG_SCF_TRCP1_1	337:342	Mutation rewiring degron network	0.2222

Kaplan plot for DOK7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DOK7

UniProt ID: Q18PE1

Entrez ID: 285489

Protein name: Protein Dok-7 (Downstream of tyrosine kinase 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DOK7 in