DegronMD

Uniprot ID: Q18PE1

Source protein: Protein Dok-7

Source gene: DOK7

Class: LIG_APCC_ABBA_1

Location: 38:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8708

ASA_SCORE: 54.0333

COIL: 0.2975

CONS_SCORE: 0.6564

DSS_SCORE: 0.1272

HELIX: 0.0868

FCONS_SCORE: 1.2005

RIG_SCORE: 0.9233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V40A	TCGA-G2-A2ES	BLCA	TCGA	MLVYKD	LIG_APCC_ABBA_1	0.6936
p.V40A	DO785	BLCA	ICGC	MLVYKD	LIG_APCC_ABBA_1	0.6936
p.R52W	TCGA-VS-A9UH	CESC	TCGA	MLVYKD	LIG_APCC_ABBA_1	0.0833
p.R52W	DO51642	CESC	ICGC	MLVYKD	LIG_APCC_ABBA_1	0.0833
p.K42N	DO229022	LICA	ICGC	MLVYKD	LIG_APCC_ABBA_1	0.5806
p.I48T	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	MLVYKD	LIG_APCC_ABBA_1	0.1944
p.I48T	SIDM00054	Pancreatic Carcinoma	GDSC	MLVYKD	LIG_APCC_ABBA_1	0.1944
p.I48T	ACH-000062	Lung Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	0.1944
p.I48T	ACH-001619	Gallbladder Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	0.1944
p.I48T	ACH-001850	Gallbladder Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	0.1944
p.I48T	ACH-002185	Pancreatic Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	0.1944
p.E46K	SIDM00346	Chronic Myelogenous Leukemia	GDSC	MLVYKD	LIG_APCC_ABBA_1	0.25
p.E46K	ACH-000301	Leukemia	CCLE	MLVYKD	LIG_APCC_ABBA_1	0.25
p.E46K	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	MLVYKD	LIG_APCC_ABBA_1	0.25
p.K49N	ACH-000637	Esophageal Cancer	CCLE	MLVYKD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q18PE1	Protein Dok-7	LIG_APCC_ABBA_1	38:43	MLVYKD	APC,CDC20,FZR1	0.8708	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons