DegronMD

Uniprot ID: Q18PE1

Source protein: Protein Dok-7

Source gene: DOK7

Class: DEG_SCF_TRCP1_1

Location: 337:342

E3 ligase: BTRC

DEGRON score: 0.9865

ASA_SCORE: 74.9167

COIL: 0.7208

CONS_SCORE: 0.5423

DSS_SCORE: 0.6015

HELIX: 0.0717

FCONS_SCORE: 1.0376

RIG_SCORE: 0.5611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S349C	DO230993	LUSC	ICGC	DSGIAT	DEG_SCF_TRCP1_1	0.1389
p.L352H	SIDM01951	Colorectal Carcinoma	GDSC	DSGIAT	DEG_SCF_TRCP1_1	0.0556
p.A341T	SIDM01259	B-Lymphoblastic Leukemia	GDSC	DSGIAT	DEG_SCF_TRCP1_1	0.6028
p.F344L	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIAT	DEG_SCF_TRCP1_1	0.2778
p.A333S	NCI-H650	lung	COSMIC	DSGIAT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q18PE1	Protein Dok-7	DEG_SCF_TRCP1_1	337:342	DSGIAT	BTRC	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons