DegronMD

Uniprot ID: Q9UPR0

Source protein: Inactive phospholipase C-like protein 2

Source gene: PLCL2

Class: DEG_SCF_TRCP1_1

Location: 50:55

E3 ligase: BTRC

DEGRON score: 0.9977

ASA_SCORE: 67.05

COIL: 0.9187

CONS_SCORE: 0.2128

DSS_SCORE: 0.4609

HELIX: 0.0342

FCONS_SCORE: 0.9432

RIG_SCORE: 0.6186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K53N	TCGA-D3-A2JP	SKCM	TCGA	DSGGVS	DEG_SCF_TRCP1_1	0.6918
p.K53N	DO47407	SKCM	ICGC	DSGGVS	DEG_SCF_TRCP1_1	0.6918
p.D54N	TCGA-FR-A8YC	SKCM	TCGA	DSGGVS	DEG_SCF_TRCP1_1	0.6932
p.D54N	DO50301	SKCM	ICGC	DSGGVS	DEG_SCF_TRCP1_1	0.6932
p.K59R	DO225412	LAML	ICGC	DSGGVS	DEG_SCF_TRCP1_1	0.2222
p.K59R	DO225429	LAML	ICGC	DSGGVS	DEG_SCF_TRCP1_1	0.2222
p.R47G	DO220860	MELA	ICGC	DSGGVS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPR0	Inactive phospholipase C-like protein 2	DEG_SCF_TRCP1_1	50:55	DSGGVS	BTRC	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons