DegronMD - Q9UPR0(PLCL2)

PLCL2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K53N	TCGA-D3-A2JP	SKCM	TCGA	DSGGVS	DEG_SCF_TRCP1_1	50:55	Mutation altering degron motif	0.6918
p.K53N	DO47407	SKCM	ICGC	DSGGVS	DEG_SCF_TRCP1_1	50:55	Mutation altering degron motif	0.6918
p.D54N	TCGA-FR-A8YC	SKCM	TCGA	DSGGVS	DEG_SCF_TRCP1_1	50:55	Mutation altering degron motif	0.6932
p.D54N	DO50301	SKCM	ICGC	DSGGVS	DEG_SCF_TRCP1_1	50:55	Mutation altering degron motif	0.6932
p.K59R	DO225412	LAML	ICGC	DSGGVS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.2222
p.K59R	DO225429	LAML	ICGC	DSGGVS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.2222
p.R47G	DO220860	MELA	ICGC	DSGGVS	DEG_SCF_TRCP1_1	50:55	Mutation rewiring degron network	0.25
p.E1119K	SIDM01175	Other Sarcomas	GDSC	PRRSLEVIP	DEG_APCC_DBOX_1	1110:1118	Mutation rewiring degron network	0.3056
p.E1119K	SW684	soft tissue	COSMIC	PRRSLEVIP	DEG_APCC_DBOX_1	1110:1118	Mutation rewiring degron network	0.3056
p.R1111H	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PRRSLEVIP	DEG_APCC_DBOX_1	1110:1118	Mutation altering degron motif	0.8244
p.R1111H	KYSE-510	oesophagus	COSMIC	PRRSLEVIP	DEG_APCC_DBOX_1	1110:1118	Mutation altering degron motif	0.8244
p.P1118H	LS-123	large intestine	COSMIC	PRRSLEVIP	DEG_APCC_DBOX_1	1110:1118	Mutation altering degron motif	0.6583

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*NOTE: the Kaplan plots were collected from OncoLnc