DegronMD

Uniprot ID: Q9UPR0

Source protein: Inactive phospholipase C-like protein 2

Source gene: PLCL2

Class: DEG_APCC_DBOX_1

Location: 1110:1118

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9244

ASA_SCORE: 92.7778

COIL: 0.7684

CONS_SCORE: 0.1083

DSS_SCORE: 0.6301

HELIX: 0.1327

FCONS_SCORE: 0.8851

RIG_SCORE: 0.74

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1119K	SIDM01175	Other Sarcomas	GDSC	PRRSLEVIP	DEG_APCC_DBOX_1	0.3056
p.E1119K	SW684	soft_tissue	COSMIC	PRRSLEVIP	DEG_APCC_DBOX_1	0.3056
p.R1111H	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PRRSLEVIP	DEG_APCC_DBOX_1	0.8244
p.R1111H	KYSE-510	oesophagus	COSMIC	PRRSLEVIP	DEG_APCC_DBOX_1	0.8244
p.P1118H	LS-123	large_intestine	COSMIC	PRRSLEVIP	DEG_APCC_DBOX_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPR0	Inactive phospholipase C-like protein 2	DEG_APCC_DBOX_1	1110:1118	PRRSLEVIP	APC,CDC20,FZR1	0.9244	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons