DegronMD

Uniprot ID: Q14692

Source protein: Ribosome biogenesis protein BMS1 homolog

Source gene: BMS1

Class: DEG_SCF_TRCP1_1

Location: 578:583

E3 ligase: BTRC

DEGRON score: 0.6288

ASA_SCORE: 66

COIL: 0.8532

CONS_SCORE: 0.2497

DSS_SCORE: 0.4462

HELIX: 0.0898

FCONS_SCORE: 0.9768

RIG_SCORE: 0.6982

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A573S	TCGA-38-4632	LUAD	TCGA	DSGHCT	DEG_SCF_TRCP1_1	0.1944
p.A573S	DO23858	LUAD	ICGC	DSGHCT	DEG_SCF_TRCP1_1	0.1944
p.E591Q	TCGA-69-A59K	LUAD	TCGA	DSGHCT	DEG_SCF_TRCP1_1	0.1111
p.E591Q	DO45335	LUAD	ICGC	DSGHCT	DEG_SCF_TRCP1_1	0.1111
p.H581Y	TCGA-DI-A1BU	UCEC	TCGA	DSGHCT	DEG_SCF_TRCP1_1	0.6118
p.H581Y	DO42023	UCEC	ICGC	DSGHCT	DEG_SCF_TRCP1_1	0.6118
p.E591K	TCGA-DK-A1AD	BLCA	TCGA	DSGHCT	DEG_SCF_TRCP1_1	0.1111
p.E591K	DO459	BLCA	ICGC	DSGHCT	DEG_SCF_TRCP1_1	0.1111
p.A584D	TCGA-L5-A893	ESCA	TCGA	DSGHCT	DEG_SCF_TRCP1_1	0.3056
p.E585K	DO225288	BRCA	ICGC	DSGHCT	DEG_SCF_TRCP1_1	0.2778
p.E585K	DO227494	BRCA	ICGC	DSGHCT	DEG_SCF_TRCP1_1	0.2778
p.V587L	SIDM00845	Burkitt's Lymphoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.2222
p.V587L	SIDM00971	Breast Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.2222
p.V587L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.2222
p.V587L	SIDM00032	Bladder Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.2222
p.D578N	SIDM00889	Cervical Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.6932
p.D578N	SIDM00176	Chondrosarcoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.6932
p.D578N	CHSA8926	bone	COSMIC	DSGHCT	DEG_SCF_TRCP1_1	0.6932
p.D578N	C-33-A	cervix	COSMIC	DSGHCT	DEG_SCF_TRCP1_1	0.6932
p.A572T	SIDM00112	Kidney Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.1667
p.A572T	ACH-000428	Kidney Cancer	CCLE	DSGHCT	DEG_SCF_TRCP1_1	0.1667
p.A572T	U031	kidney	COSMIC	DSGHCT	DEG_SCF_TRCP1_1	0.1667
p.L568V	SIDM01446	Glioblastoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.0556
p.E586G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DSGHCT	DEG_SCF_TRCP1_1	0.25
p.E586G	ACH-000728	Leukemia	CCLE	DSGHCT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14692	Ribosome biogenesis protein BMS1 homolog	DEG_SCF_TRCP1_1	578:583	DSGHCT	BTRC	0.6288	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGHCT

Degron related mutations and impact score

Drug responses associated with BMS1 mutations

All proteins holding degron of DSGHCT