DegronMD - Q14692(BMS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1200L	TCGA-05-5425	LUAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200L	DO26270	LUAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200G	TCGA-13-0800	OV	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200G	DO28611	OV	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.G402W	TCGA-23-1021	OV	TCGA	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.1944
p.G402W	TCGA-23-1021	OV	TCGA	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1944
p.G402W	DO32183	OV	ICGC	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.1944
p.G402W	DO32183	OV	ICGC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1944
p.G344C	TCGA-34-2600	LUSC	TCGA	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1944
p.G344C	DO27081	LUSC	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1944
p.A573S	TCGA-38-4632	LUAD	TCGA	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1944
p.A573S	DO23858	LUAD	ICGC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1944
p.K1252N	TCGA-44-7662	LUAD	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.2778
p.K1252N	DO23597	LUAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.2778
p.E591Q	TCGA-69-A59K	LUAD	TCGA	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1111
p.E591Q	DO45335	LUAD	ICGC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1111
p.R1268T	TCGA-78-7539	LUAD	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.1667
p.R1268T	DO26210	LUAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.1667
p.V345L	TCGA-A8-A07L	BRCA	TCGA	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.2222
p.V345L	DO2377	BRCA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.2222
p.T393M	TCGA-AA-3864	COAD	TCGA	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6312
p.T393M	TCGA-AA-3864	COAD	TCGA	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.6312
p.T393M	DO8490	COAD	ICGC	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6312
p.T393M	DO8490	COAD	ICGC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.6312
p.R1250W	TCGA-AD-6895	COAD	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.2222
p.R1250W	TCGA-AP-A056	UCEC	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.2222
p.R1250W	DO8938	COAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.2222
p.R1250W	DO43971	UCEC	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.2222
p.T1216M	TCGA-AP-A1DV	UCEC	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.T1216M	TCGA-FI-A2D5	UCEC	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.T1216M	DO43186	UCEC	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.T1216M	DO41331	UCEC	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.P1196S	TCGA-B5-A3FC	UCEC	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.1111
p.P1196S	DO41871	UCEC	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.1111
p.R1200H	TCGA-BR-6452	STAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200H	DO38404	STAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.P1196L	TCGA-BR-8487	STAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.1111
p.P1196L	DO47867	STAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.1111
p.E1246K	TCGA-CG-5728	STAD	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.1111
p.E1246K	DO38619	STAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.1111
p.H581Y	TCGA-DI-A1BU	UCEC	TCGA	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6118
p.H581Y	DO42023	UCEC	ICGC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6118
p.E591K	TCGA-DK-A1AD	BLCA	TCGA	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1111
p.E591K	DO459	BLCA	ICGC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1111
p.A584D	TCGA-L5-A893	ESCA	TCGA	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.3056
p.S1219N	TCGA-VQ-A8P2	STAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219N	DO51761	STAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.5833
p.R1200C	TCGA-XK-AAIW	PRAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	DO51407	PRAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	SIDM00568	Gastric Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	SIDM00616	Hepatocellular Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	SIDM00531	Pancreatic Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	ACH-000213	Pancreatic Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	ACH-000247	Gastric Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	ACH-000476	Liver Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	ACH-000693	Esophageal Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	ACH-001853	Bile Duct Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	JHH-4	liver	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	HuP-T4	pancreas	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	OCUM-1	stomach	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.R1200C	KYSE-180	oesophagus	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2222
p.A1213P	TCGA-Y8-A896	KIRP	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.3056
p.A1213P	DO49803	KIRP	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.3056
p.E585K	DO225288	BRCA	ICGC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.2778
p.E585K	DO227494	BRCA	ICGC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.2778
p.Q1262R	DO8858	COAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.6218
p.E365K	DO228187	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.0556
p.L339V	DO228945	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.0556
p.Y353C	DO228945	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation altering degron motif	0.7087
p.V342F	DO228986	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1389
p.G343E	DO229058	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1667
p.G343E	DO229057	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1667
p.D348E	DO229268	THCA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.3056
p.H1218R	SIDM00371	Pancreatic Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.1667
p.H1218R	SUIT-2	pancreas	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.1667
p.V587L	SIDM00845	Burkitt's Lymphoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.2222
p.V587L	SIDM00971	Breast Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.2222
p.V587L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.2222
p.V587L	SIDM00032	Bladder Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.2222
p.S1219T	SIDM01040	Ovarian Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219T	SIDM00596	Endometrial Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219T	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219T	SIDM00302	Other Solid Cancers	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.5833
p.D578N	SIDM00889	Cervical Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6932
p.D578N	SIDM00176	Chondrosarcoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6932
p.D578N	CHSA8926	bone	COSMIC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6932
p.D578N	C-33-A	cervix	COSMIC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6932
p.R1260I	SIDM00683	Prostate Carcinoma	GDSC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.6991
p.R1260I	ACH-000977	lymph node	CCLE	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.6991
p.R1260I	LNCaP-Clone-FGC	prostate	COSMIC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.6991
p.L1214V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2778
p.L1214V	ACH-000980	Lung Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2778
p.L1214V	NCI-H1155	lung	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.2778
p.A572T	SIDM00112	Kidney Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1667
p.A572T	ACH-000428	Kidney Cancer	CCLE	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1667
p.A572T	U031	kidney	COSMIC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.1667
p.V1198I	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.1667
p.V1198I	KYSE-50	oesophagus	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.1667
p.E1201K	SIDM00534	Colorectal Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.25
p.E1201K	ACH-000986	Colon/Colorectal Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.25
p.E1201K	HT-115	large intestine	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.25
p.I406V	SIDM00783	Colorectal Carcinoma	GDSC	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.I406V	SIDM00783	Colorectal Carcinoma	GDSC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0833
p.I406V	ACH-000971	Colon/Colorectal Cancer	CCLE	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.I406V	ACH-000971	Colon/Colorectal Cancer	CCLE	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0833
p.I406V	HCT-116	large intestine	COSMIC	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation rewiring degron network	0.0833
p.I406V	HCT-116	large intestine	COSMIC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0833
p.Q1262H	SIDM00901	Endometrial Carcinoma	GDSC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.647
p.Q1262H	ACH-000940	Endometrial/Uterine Cancer	CCLE	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.647
p.Q1262H	AN3-CA	endometrium	COSMIC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.647
p.L568V	SIDM01446	Glioblastoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.0556
p.E586G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.25
p.E586G	ACH-000728	Leukemia	CCLE	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation rewiring degron network	0.25
p.V392L	SIDM01619	Endometrial Carcinoma	GDSC	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.5654
p.V392L	SIDM01619	Endometrial Carcinoma	GDSC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.5654
p.V392L	ACH-000984	Endometrial/Uterine Cancer	CCLE	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.5654
p.V392L	ACH-000984	Endometrial/Uterine Cancer	CCLE	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.5654
p.R1267T	ACH-000299	Leukemia	CCLE	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation rewiring degron network	0.1944
p.A351T	ACH-000467	Colon/Colorectal Cancer	CCLE	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation altering degron motif	0.6028
p.A351T	HCC-56	large intestine	COSMIC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation altering degron motif	0.6028
p.R391Q	ACH-001322	Sarcoma	CCLE	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7329
p.V361I	ACH-001845	Bile Duct Cancer	CCLE	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation rewiring degron network	0.1667
p.R1195G	ACH-002256	Leukemia	CCLE	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.0833
p.R1195G	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMS1

UniProt ID: Q14692

Entrez ID: 9790

Protein name: Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMS1 in