DegronMD - Q14692(BMS1)

FUNCTION: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus. {ECO:0000250|UniProtKB:Q08965}.

GO - Biological processes (BP): endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]

GO - Molecular function (MF): ATP binding [GO:0005524]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]

GO - Cellular component (CC): 90S preribosome [GO:0030686]; chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R391Q	ACH-001322	Sarcoma	CCLE	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7329
p.Y353C	DO228945	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	349:355	Mutation altering degron motif	0.7087
p.R1260I	SIDM00683	Prostate Carcinoma	GDSC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.6991
p.R1260I	ACH-000977	lymph node	CCLE	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.6991
p.R1260I	LNCaP-Clone-FGC	prostate	COSMIC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.6991
p.D578N	SIDM00889	Cervical Carcinoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6932
p.D578N	SIDM00176	Chondrosarcoma	GDSC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6932
p.D578N	CHSA8926	bone	COSMIC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6932
p.D578N	C-33-A	cervix	COSMIC	DSGHCT	DEG_SCF_TRCP1_1	578:583	Mutation altering degron motif	0.6932
p.T1216M	TCGA-AP-A1DV	UCEC	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.T1216M	TCGA-FI-A2D5	UCEC	TCGA	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.T1216M	DO43186	UCEC	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.T1216M	DO41331	UCEC	ICGC	ERKILALLD	DEG_APCC_DBOX_1	1204:1212	Mutation blocking phosphorylation signal	0.6667
p.Q1262H	SIDM00901	Endometrial Carcinoma	GDSC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.647
p.Q1262H	ACH-000940	Endometrial/Uterine Cancer	CCLE	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.647
p.Q1262H	AN3-CA	endometrium	COSMIC	LRKKLFRIQ	DEG_APCC_DBOX_1	1254:1262	Mutation altering degron motif	0.647
p.T393M	TCGA-AA-3864	COAD	TCGA	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6312
p.T393M	TCGA-AA-3864	COAD	TCGA	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.6312
p.T393M	DO8490	COAD	ICGC	VTLFSD	LIG_APCC_ABBA_1	392:397	Mutation altering degron motif	0.6312
p.T393M	DO8490	COAD	ICGC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.6312

Showing 1 to 20 of 126 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMS1

UniProt ID: Q14692

Entrez ID: 9790

Protein name: Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMS1 in