DegronMD

Uniprot ID: Q14692

Source protein: Ribosome biogenesis protein BMS1 homolog

Source gene: BMS1

Class: LIG_APCC_ABBAyCdc20_2

Location: 391:397

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9924

ASA_SCORE: 69.8286

COIL: 0.6421

CONS_SCORE: 0.3786

DSS_SCORE: 0.4293

HELIX: 0.2184

FCONS_SCORE: 1.1378

RIG_SCORE: 0.7374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G402W	TCGA-23-1021	OV	TCGA	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G402W	DO32183	OV	ICGC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.T393M	TCGA-AA-3864	COAD	TCGA	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.6312
p.T393M	DO8490	COAD	ICGC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.6312
p.I406V	SIDM00783	Colorectal Carcinoma	GDSC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.I406V	ACH-000971	Colon/Colorectal Cancer	CCLE	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.I406V	HCT-116	large_intestine	COSMIC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V392L	SIDM01619	Endometrial Carcinoma	GDSC	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.5654
p.V392L	ACH-000984	Endometrial/Uterine Cancer	CCLE	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.5654
p.R391Q	ACH-001322	Sarcoma	CCLE	RVTLFSD	LIG_APCC_ABBAyCdc20_2	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14692	Ribosome biogenesis protein BMS1 homolog	LIG_APCC_ABBAyCdc20_2	391:397	RVTLFSD	APC,CDC20,FZR1	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons