DegronMD

Uniprot ID: Q14692

Source protein: Ribosome biogenesis protein BMS1 homolog

Source gene: BMS1

Class: DEG_APCC_DBOX_1

Location: 1254:1262

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7259

ASA_SCORE: 114.0333

COIL: 0.2203

CONS_SCORE: 0.3422

DSS_SCORE: 0.5871

HELIX: 0.7838

FCONS_SCORE: 1.1157

RIG_SCORE: 0.7911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1252N	TCGA-44-7662	LUAD	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	0.2778
p.K1252N	DO23597	LUAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.2778
p.R1268T	TCGA-78-7539	LUAD	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	0.1667
p.R1268T	DO26210	LUAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.1667
p.R1250W	TCGA-AD-6895	COAD	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	0.2222
p.R1250W	TCGA-AP-A056	UCEC	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	0.2222
p.R1250W	DO8938	COAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.2222
p.R1250W	DO43971	UCEC	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.2222
p.E1246K	TCGA-CG-5728	STAD	TCGA	LRKKLFRIQ	DEG_APCC_DBOX_1	0.1111
p.E1246K	DO38619	STAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.1111
p.Q1262R	DO8858	COAD	ICGC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.6218
p.R1260I	SIDM00683	Prostate Carcinoma	GDSC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.6991
p.R1260I	ACH-000977	lymph_node	CCLE	LRKKLFRIQ	DEG_APCC_DBOX_1	0.6991
p.R1260I	LNCaP-Clone-FGC	prostate	COSMIC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.6991
p.Q1262H	SIDM00901	Endometrial Carcinoma	GDSC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.647
p.Q1262H	ACH-000940	Endometrial/Uterine Cancer	CCLE	LRKKLFRIQ	DEG_APCC_DBOX_1	0.647
p.Q1262H	AN3-CA	endometrium	COSMIC	LRKKLFRIQ	DEG_APCC_DBOX_1	0.647
p.R1267T	ACH-000299	Leukemia	CCLE	LRKKLFRIQ	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14692	Ribosome biogenesis protein BMS1 homolog	DEG_APCC_DBOX_1	1254:1262	LRKKLFRIQ	APC,CDC20,FZR1	0.7259	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons