DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ERKILALLD
Uniprot ID:
Q14692
Source protein:
Ribosome biogenesis protein BMS1 homolog
Source gene:
BMS1
Class:
DEG_APCC_DBOX_1
Location:
1204:1212
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9505
ASA_SCORE:
75.1111
COIL:
0.022
CONS_SCORE:
0.4432
DSS_SCORE:
0.4182
HELIX:
0.9764
FCONS_SCORE:
1.1741
RIG_SCORE:
0.81
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1216M
TCGA-AP-A1DV
UCEC
TCGA
ERKILALLD
DEG_APCC_DBOX_1
0.6667
p.T1216M
TCGA-FI-A2D5
UCEC
TCGA
ERKILALLD
DEG_APCC_DBOX_1
0.6667
p.T1216M
DO43186
UCEC
ICGC
ERKILALLD
DEG_APCC_DBOX_1
0.6667
p.T1216M
DO41331
UCEC
ICGC
ERKILALLD
DEG_APCC_DBOX_1
0.6667
p.S1219N
TCGA-VQ-A8P2
STAD
TCGA
ERKILALLD
DEG_APCC_DBOX_1
0.5833
p.S1219N
DO51761
STAD
ICGC
ERKILALLD
DEG_APCC_DBOX_1
0.5833
p.S1219T
SIDM01040
Ovarian Carcinoma
GDSC
ERKILALLD
DEG_APCC_DBOX_1
0.5833
p.S1219T
SIDM01028
Esophageal Squamous Cell Carcinoma
GDSC
ERKILALLD
DEG_APCC_DBOX_1
0.5833
p.S1219T
SIDM00596
Endometrial Carcinoma
GDSC
ERKILALLD
DEG_APCC_DBOX_1
0.5833
p.S1219T
SIDM01031
Esophageal Squamous Cell Carcinoma
GDSC
ERKILALLD
DEG_APCC_DBOX_1
0.5833
p.S1219T
SIDM00302
Other Solid Cancers
GDSC
ERKILALLD
DEG_APCC_DBOX_1
0.5833
p.A1213P
TCGA-Y8-A896
KIRP
TCGA
ERKILALLD
DEG_APCC_DBOX_1
0.3056
p.A1213P
DO49803
KIRP
ICGC
ERKILALLD
DEG_APCC_DBOX_1
0.3056
p.L1214V
SIDM00651
Non-Small Cell Lung Carcinoma
GDSC
ERKILALLD
DEG_APCC_DBOX_1
0.2778
p.L1214V
ACH-000980
Lung Cancer
CCLE
ERKILALLD
DEG_APCC_DBOX_1
0.2778
p.L1214V
NCI-H1155
lung
COSMIC
ERKILALLD
DEG_APCC_DBOX_1
0.2778
p.E1201K
SIDM00534
Colorectal Carcinoma
GDSC
ERKILALLD
DEG_APCC_DBOX_1
0.25
p.E1201K
ACH-000986
Colon/Colorectal Cancer
CCLE
ERKILALLD
DEG_APCC_DBOX_1
0.25
p.E1201K
HT-115
large_intestine
COSMIC
ERKILALLD
DEG_APCC_DBOX_1
0.25
p.R1200L
TCGA-05-5425
LUAD
TCGA
ERKILALLD
DEG_APCC_DBOX_1
0.2222
p.R1200L
DO26270
LUAD
ICGC
ERKILALLD
DEG_APCC_DBOX_1
0.2222
p.R1200G
TCGA-13-0800
OV
TCGA
ERKILALLD
DEG_APCC_DBOX_1
0.2222
p.R1200G
DO28611
OV
ICGC
ERKILALLD
DEG_APCC_DBOX_1
0.2222
p.R1200H
TCGA-BR-6452
STAD
TCGA
ERKILALLD
DEG_APCC_DBOX_1
0.2222
p.R1200H
DO38404
STAD
ICGC
ERKILALLD
DEG_APCC_DBOX_1
0.2222
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Drug responses associated with BMS1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of ERKILALLD
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14692
Ribosome biogenesis protein BMS1 homolog
DEG_APCC_DBOX_1
1204:1212
ERKILALLD
APC,CDC20,FZR1
0.9505
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