DegronMD

Uniprot ID: Q14692

Source protein: Ribosome biogenesis protein BMS1 homolog

Source gene: BMS1

Class: DEG_APCC_DBOX_1

Location: 1204:1212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9505

ASA_SCORE: 75.1111

COIL: 0.022

CONS_SCORE: 0.4432

DSS_SCORE: 0.4182

HELIX: 0.9764

FCONS_SCORE: 1.1741

RIG_SCORE: 0.81

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1200L	TCGA-05-5425	LUAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200L	DO26270	LUAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200G	TCGA-13-0800	OV	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200G	DO28611	OV	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.T1216M	TCGA-AP-A1DV	UCEC	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.6667
p.T1216M	TCGA-FI-A2D5	UCEC	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.6667
p.T1216M	DO43186	UCEC	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.6667
p.T1216M	DO41331	UCEC	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.6667
p.P1196S	TCGA-B5-A3FC	UCEC	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.1111
p.P1196S	DO41871	UCEC	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.1111
p.R1200H	TCGA-BR-6452	STAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200H	DO38404	STAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.P1196L	TCGA-BR-8487	STAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.1111
p.P1196L	DO47867	STAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.1111
p.S1219N	TCGA-VQ-A8P2	STAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.5833
p.S1219N	DO51761	STAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.5833
p.R1200C	TCGA-XK-AAIW	PRAD	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	DO51407	PRAD	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	SIDM00568	Gastric Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	SIDM00616	Hepatocellular Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	SIDM00531	Pancreatic Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	ACH-000213	Pancreatic Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	ACH-000247	Gastric Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	ACH-000476	Liver Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	ACH-000693	Esophageal Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	ACH-001853	Bile Duct Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	JHH-4	liver	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	HuP-T4	pancreas	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	OCUM-1	stomach	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.R1200C	KYSE-180	oesophagus	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.2222
p.A1213P	TCGA-Y8-A896	KIRP	TCGA	ERKILALLD	DEG_APCC_DBOX_1	0.3056
p.A1213P	DO49803	KIRP	ICGC	ERKILALLD	DEG_APCC_DBOX_1	0.3056
p.H1218R	SIDM00371	Pancreatic Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.1667
p.H1218R	SUIT-2	pancreas	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.1667
p.S1219T	SIDM01040	Ovarian Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.5833
p.S1219T	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.5833
p.S1219T	SIDM00596	Endometrial Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.5833
p.S1219T	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.5833
p.S1219T	SIDM00302	Other Solid Cancers	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.5833
p.L1214V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.2778
p.L1214V	ACH-000980	Lung Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	0.2778
p.L1214V	NCI-H1155	lung	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.2778
p.V1198I	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.1667
p.V1198I	KYSE-50	oesophagus	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.1667
p.E1201K	SIDM00534	Colorectal Carcinoma	GDSC	ERKILALLD	DEG_APCC_DBOX_1	0.25
p.E1201K	ACH-000986	Colon/Colorectal Cancer	CCLE	ERKILALLD	DEG_APCC_DBOX_1	0.25
p.E1201K	HT-115	large_intestine	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.25
p.R1195G	ACH-002256	Leukemia	CCLE	ERKILALLD	DEG_APCC_DBOX_1	0.0833
p.R1195G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ERKILALLD	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERKILALLD

Degron related mutations and impact score

Drug responses associated with BMS1 mutations

All proteins holding degron of ERKILALLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14692	Ribosome biogenesis protein BMS1 homolog	DEG_APCC_DBOX_1	1204:1212	ERKILALLD	APC,CDC20,FZR1	0.9505	More...