DegronMD

Uniprot ID: Q14692

Source protein: Ribosome biogenesis protein BMS1 homolog

Source gene: BMS1

Class: LIG_APCC_ABBAyCdc20_2

Location: 349:355

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6611

ASA_SCORE: 64.2286

COIL: 0.5366

CONS_SCORE: 0.6769

DSS_SCORE: 0.1347

HELIX: 0.0251

FCONS_SCORE: 1.3166

RIG_SCORE: 0.8782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G344C	TCGA-34-2600	LUSC	TCGA	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G344C	DO27081	LUSC	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.1944
p.V345L	TCGA-A8-A07L	BRCA	TCGA	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.V345L	DO2377	BRCA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E365K	DO228187	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.L339V	DO228945	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.Y353C	DO228945	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.7087
p.V342F	DO228986	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.G343E	DO229058	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G343E	DO229057	LICA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D348E	DO229268	THCA	ICGC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A351T	ACH-000467	Colon/Colorectal Cancer	CCLE	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.6028
p.A351T	HCC-56	large_intestine	COSMIC	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.6028
p.V361I	ACH-001845	Bile Duct Cancer	CCLE	KDAVYVD	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14692	Ribosome biogenesis protein BMS1 homolog	LIG_APCC_ABBAyCdc20_2	349:355	KDAVYVD	APC,CDC20,FZR1	0.6611	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons