DegronMD

Uniprot ID: Q9Y6M5

Source protein: Zinc transporter 1

Source gene: SLC30A1

Class: DEG_SCF_TRCP1_1

Location: 143:149

E3 ligase: BTRC

DEGRON score: 0.9853

ASA_SCORE: 50.8

COIL: 0.8197

CONS_SCORE: 0.4738

DSS_SCORE: 0.6338

HELIX: 0.0704

FCONS_SCORE: 1.1175

RIG_SCORE: 0.4774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D143V	TCGA-37-4141	LUSC	TCGA	DSGHGHS	DEG_SCF_TRCP1_1	0.7785
p.D143V	DO26862	LUSC	ICGC	DSGHGHS	DEG_SCF_TRCP1_1	0.7785
p.F134L	DO229029	LICA	ICGC	DSGHGHS	DEG_SCF_TRCP1_1	0.0833
p.H155Q	DO229008	LICA	ICGC	DSGHGHS	DEG_SCF_TRCP1_1	0.1667
p.H150Q	DO230931	LUSC	ICGC	DSGHGHS	DEG_SCF_TRCP1_1	0.3056
p.H150Q	DO224548	LUSC	ICGC	DSGHGHS	DEG_SCF_TRCP1_1	0.3056
p.H135Y	DO31420	OV	ICGC	DSGHGHS	DEG_SCF_TRCP1_1	0.1111
p.H137Y	ACH-000945	Lung Cancer	CCLE	DSGHGHS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6M5	Zinc transporter 1	DEG_SCF_TRCP1_1	143:149	DSGHGHS	BTRC	0.9853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons