DegronMD

Uniprot ID: Q9C0K7

Source protein: STE20-related kinase adapter protein beta

Source gene: STRADB

Class: DEG_SCF_TRCP1_1

Location: 309:315

E3 ligase: BTRC

DEGRON score: 0.999

ASA_SCORE: 65.0143

COIL: 0.769

CONS_SCORE: 0.5316

DSS_SCORE: 0.5178

HELIX: 0.0954

FCONS_SCORE: 1.5618

RIG_SCORE: 0.647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D309H	TCGA-D6-A4ZB	HNSC	TCGA	DSGIGES	DEG_SCF_TRCP1_1	0.7688
p.D309H	DO44446	HNSC	ICGC	DSGIGES	DEG_SCF_TRCP1_1	0.7688
p.G307D	SIDM01608	Endometrial Carcinoma	GDSC	DSGIGES	DEG_SCF_TRCP1_1	0.2778
p.G307D	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSGIGES	DEG_SCF_TRCP1_1	0.2778
p.S299C	ACH-000831	Endometrial/Uterine Cancer	CCLE	DSGIGES	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0K7	STE20-related kinase adapter protein beta	DEG_SCF_TRCP1_1	309:315	DSGIGES	BTRC	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons