DegronMD

Uniprot ID: Q9HBU9

Source protein: Popeye domain-containing protein 2

Source gene: POPDC2

Class: DEG_SCF_TRCP1_1

Location: 332:338

E3 ligase: BTRC

DEGRON score: 0.9992

ASA_SCORE: 76.3143

COIL: 0.8579

CONS_SCORE: 0.3302

DSS_SCORE: 0.5371

HELIX: 0.1076

FCONS_SCORE: 1.1911

RIG_SCORE: 0.7039

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R339G	TCGA-60-2722	LUSC	TCGA	DSGILAS	DEG_SCF_TRCP1_1	0.3056
p.R339G	DO26798	LUSC	ICGC	DSGILAS	DEG_SCF_TRCP1_1	0.3056
p.A326V	TCGA-AX-A1CE	UCEC	TCGA	DSGILAS	DEG_SCF_TRCP1_1	0.1667
p.A326V	DO42280	UCEC	ICGC	DSGILAS	DEG_SCF_TRCP1_1	0.1667
p.I340M	TCGA-BH-A0C7	BRCA	TCGA	DSGILAS	DEG_SCF_TRCP1_1	0.2778
p.I340M	DO4269	BRCA	ICGC	DSGILAS	DEG_SCF_TRCP1_1	0.2778
p.S346Y	TCGA-DF-A2KU	UCEC	TCGA	DSGILAS	DEG_SCF_TRCP1_1	0.5556
p.S346Y	DO223286	UCEC	ICGC	DSGILAS	DEG_SCF_TRCP1_1	0.5556
p.R325Q	DO233879	GACA	ICGC	DSGILAS	DEG_SCF_TRCP1_1	0.1389
p.R325Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGILAS	DEG_SCF_TRCP1_1	0.1389
p.R325Q	ACH-000980	Lung Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	0.1389
p.R325Q	NCI-H1155	lung	COSMIC	DSGILAS	DEG_SCF_TRCP1_1	0.1389
p.P323H	DO229027	LICA	ICGC	DSGILAS	DEG_SCF_TRCP1_1	0.0833
p.V348I	DO232968	PEME	ICGC	DSGILAS	DEG_SCF_TRCP1_1	0.0556
p.S333N	DO46973	RECA	ICGC	DSGILAS	DEG_SCF_TRCP1_1	0.818
p.S333N	ACH-002396	Bone Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	0.818
p.S333N	Sarc9371	bone	COSMIC	DSGILAS	DEG_SCF_TRCP1_1	0.818
p.P323L	SIDM00265	Ewing's Sarcoma	GDSC	DSGILAS	DEG_SCF_TRCP1_1	0.0833
p.P323L	ACH-002104	Bone Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	0.0833
p.P323L	ES3	bone	COSMIC	DSGILAS	DEG_SCF_TRCP1_1	0.0833
p.G337V	ACH-000845	Lung Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	0.7532
p.G337V	ACH-002175	Lung Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	0.7532
p.G337V	NCI-H740	lung	COSMIC	DSGILAS	DEG_SCF_TRCP1_1	0.7532
p.R325W	ACH-002005	Skin Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBU9	Popeye domain-containing protein 2	DEG_SCF_TRCP1_1	332:338	DSGILAS	BTRC	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons