DegronMD - Q9HBU9(POPDC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R339G	TCGA-60-2722	LUSC	TCGA	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.3056
p.R339G	DO26798	LUSC	ICGC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.3056
p.A326V	TCGA-AX-A1CE	UCEC	TCGA	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.1667
p.A326V	DO42280	UCEC	ICGC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.1667
p.I340M	TCGA-BH-A0C7	BRCA	TCGA	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.2778
p.I340M	DO4269	BRCA	ICGC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.2778
p.Q298E	TCGA-CN-6013	HNSC	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	304:311	Mutation rewiring degron network	0.1667
p.Q298E	DO15975	HNSC	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	304:311	Mutation rewiring degron network	0.1667
p.S346Y	TCGA-DF-A2KU	UCEC	TCGA	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation blocking phosphorylation signal	0.5556
p.S346Y	DO223286	UCEC	ICGC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation blocking phosphorylation signal	0.5556
p.P308L	TCGA-EE-A29L	SKCM	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	304:311	Mutation altering degron motif	0.7582
p.P308L	DO222599	MELA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	304:311	Mutation altering degron motif	0.7582
p.P308L	DO37835	SKCM	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	304:311	Mutation altering degron motif	0.7582
p.R325Q	DO233879	GACA	ICGC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.1389
p.R325Q	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.1389
p.R325Q	ACH-000980	Lung Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.1389
p.R325Q	NCI-H1155	lung	COSMIC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.1389
p.P323H	DO229027	LICA	ICGC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.0833
p.P297H	DO229031	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	304:311	Mutation rewiring degron network	0.1389
p.A321E	DO229035	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	304:311	Mutation rewiring degron network	0.0556
p.V348I	DO232968	PEME	ICGC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.0556
p.S333N	DO46973	RECA	ICGC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation altering degron motif	0.818
p.S333N	ACH-002396	Bone Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation altering degron motif	0.818
p.S333N	Sarc9371	bone	COSMIC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation altering degron motif	0.818
p.P323L	SIDM00265	Ewing's Sarcoma	GDSC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.0833
p.P323L	ACH-002104	Bone Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.0833
p.P323L	ES3	bone	COSMIC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.0833
p.G337V	ACH-000845	Lung Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation altering degron motif	0.7532
p.G337V	ACH-002175	Lung Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation altering degron motif	0.7532
p.G337V	NCI-H740	lung	COSMIC	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation altering degron motif	0.7532
p.R325W	ACH-002005	Skin Cancer	CCLE	DSGILAS	DEG_SCF_TRCP1_1	332:338	Mutation rewiring degron network	0.1389

Kaplan plot for POPDC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POPDC2

UniProt ID: Q9HBU9

Entrez ID: 64091

Protein name: Popeye domain-containing protein 2 (Popeye protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POPDC2 in