DegronMD

Uniprot ID: Q9HBU9

Source protein: Popeye domain-containing protein 2

Source gene: POPDC2

Class: DEG_SCF_FBW7_1

Location: 304:311

E3 ligase: FBXW7

DEGRON score: 0.7425

ASA_SCORE: 92.2875

COIL: 0.9133

CONS_SCORE: 0.2883

DSS_SCORE: 0.7611

HELIX: 0.069

FCONS_SCORE: 1.0107

RIG_SCORE: 0.5938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q298E	TCGA-CN-6013	HNSC	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.1667
p.Q298E	DO15975	HNSC	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.1667
p.P308L	TCGA-EE-A29L	SKCM	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.7582
p.P308L	DO222599	MELA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.7582
p.P308L	DO37835	SKCM	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.7582
p.P297H	DO229031	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.1389
p.A321E	DO229035	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBU9	Popeye domain-containing protein 2	DEG_SCF_FBW7_1	304:311	LQQTPPCS	FBXW7	0.7425	More...
Q68CR7	Leucine-rich repeat-containing protein 66	DEG_SCF_FBW7_1	852:859	LQQTPPCS	FBXW7	0.9839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons