DegronMD

Uniprot ID: Q68CR7

Source protein: Leucine-rich repeat-containing protein 66

Source gene: LRRC66

Class: DEG_SCF_FBW7_1

Location: 852:859

E3 ligase: FBXW7

DEGRON score: 0.9839

ASA_SCORE: 85.2625

COIL: 0.9236

CONS_SCORE: 0.4043

DSS_SCORE: 0.5044

HELIX: 0.03

FCONS_SCORE: 0.961

RIG_SCORE: 0.7031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A869D	TCGA-50-6595	LUAD	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.0556
p.A869D	DO23654	LUAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.0556
p.Q853H	TCGA-95-7947	LUAD	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.647
p.Q853H	DO26404	LUAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.647
p.A860V	TCGA-B5-A1MX	UCEC	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.3056
p.A860V	DO41999	UCEC	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.3056
p.D867N	TCGA-CV-A45P	HNSC	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.1111
p.D867N	DO219026	HNSC	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.1111
p.D867N	SIDM00082	Melanoma	GDSC	LQQTPPCS	DEG_SCF_FBW7_1	0.1111
p.D867N	ACH-001190	Skin Cancer	CCLE	LQQTPPCS	DEG_SCF_FBW7_1	0.1111
p.D867N	SK-MEL-2	skin	COSMIC	LQQTPPCS	DEG_SCF_FBW7_1	0.1111
p.P863T	TCGA-CV-A460	HNSC	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.2222
p.P863T	DO52065	HNSC	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.2222
p.P857L	TCGA-DA-A95Z	SKCM	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.6471
p.P857L	DO219481	SKCM	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.6471
p.S847L	TCGA-EB-A4IS	SKCM	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.1944
p.S847L	DO47281	SKCM	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.1944
p.P863S	TCGA-EE-A29V	SKCM	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.2222
p.P863S	DO229453	SKCA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.2222
p.P863S	DO38006	SKCM	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.2222
p.V851I	TCGA-L5-A4OI	ESCA	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	0.3056
p.V851I	DO8264	COAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.3056
p.E861D	DO50450	ESAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.2778
p.E861D	DO234343	ESAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.2778
p.Q853K	DO229019	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.5833
p.Q854K	DO229022	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.5833
p.P857T	DO229036	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.5919
p.P866S	DO219873	SKCA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	0.1389
p.D865Y	ACH-000961	Endometrial/Uterine Cancer	CCLE	LQQTPPCS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBU9	Popeye domain-containing protein 2	DEG_SCF_FBW7_1	304:311	LQQTPPCS	FBXW7	0.7425	More...
Q68CR7	Leucine-rich repeat-containing protein 66	DEG_SCF_FBW7_1	852:859	LQQTPPCS	FBXW7	0.9839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQQTPPCS

Degron related mutations and impact score

Drug responses associated with LRRC66 mutations

All proteins holding degron of LQQTPPCS