DegronMD - Q68CR7(LRRC66)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A869D	TCGA-50-6595	LUAD	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.0556
p.A869D	DO23654	LUAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.0556
p.F458L	TCGA-60-2698	LUSC	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1667
p.F458L	TCGA-66-2783	LUSC	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1667
p.F458L	TCGA-CV-6961	HNSC	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1667
p.F458L	DO14566	HNSC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1667
p.F458L	DO26469	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1667
p.F458L	DO26452	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1667
p.Q853H	TCGA-95-7947	LUAD	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation altering degron motif	0.647
p.Q853H	DO26404	LUAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation altering degron motif	0.647
p.A467T	TCGA-AJ-A3OK	UCEC	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.7139
p.A467T	TCGA-EO-A22R	UCEC	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.7139
p.A467T	DO227657	COCA	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.7139
p.A467T	DO43602	UCEC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.7139
p.A467T	DO42713	UCEC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.7139
p.A860V	TCGA-B5-A1MX	UCEC	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.3056
p.A860V	DO41999	UCEC	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.3056
p.A467S	TCGA-BR-6452	STAD	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.7588
p.A467S	DO38404	STAD	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.7588
p.D867N	TCGA-CV-A45P	HNSC	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1111
p.D867N	DO219026	HNSC	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1111
p.D867N	SIDM00082	Melanoma	GDSC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1111
p.D867N	ACH-001190	Skin Cancer	CCLE	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1111
p.D867N	SK-MEL-2	skin	COSMIC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1111
p.P863T	TCGA-CV-A460	HNSC	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.2222
p.P863T	DO52065	HNSC	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.2222
p.K684N	TCGA-D3-A2JL	SKCM	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation substituting flanking lysine	0.3333
p.K684N	DO47278	SKCM	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation substituting flanking lysine	0.3333
p.P857L	TCGA-DA-A95Z	SKCM	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation altering degron motif	0.6471
p.P857L	DO219481	SKCM	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation altering degron motif	0.6471
p.S847L	TCGA-EB-A4IS	SKCM	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1944
p.S847L	DO47281	SKCM	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1944
p.P863S	TCGA-EE-A29V	SKCM	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.2222
p.P863S	DO229453	SKCA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.2222
p.P863S	DO38006	SKCM	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.2222
p.G476E	TCGA-EE-A2A2	SKCM	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.2222
p.G476E	DO37583	SKCM	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.2222
p.P670S	TCGA-EE-A2MJ	SKCM	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.2222
p.P670S	DO38099	SKCM	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.2222
p.P666L	TCGA-FS-A1ZW	SKCM	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.1111
p.P666L	DO37519	SKCM	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.1111
p.R477T	TCGA-FW-A3R5	SKCM	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1944
p.R477T	DO37406	SKCM	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1944
p.R672K	TCGA-GN-A266	SKCM	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.2778
p.R672K	DO37432	SKCM	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.2778
p.P471S	TCGA-GN-A4U7	SKCM	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.6752
p.P471S	DO222847	MELA	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.6752
p.P471S	DO51258	SKCM	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.6752
p.Q462H	TCGA-IB-7651	PAAD	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.2778
p.Q462H	DO46657	PAAD	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.2778
p.D481Y	TCGA-L3-A4E7	LUSC	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.0833
p.D481Y	DO45458	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.0833
p.V851I	TCGA-L5-A4OI	ESCA	TCGA	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.3056
p.V851I	DO8264	COAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.3056
p.Q462K	TCGA-NC-A5HK	LUSC	TCGA	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.2778
p.Q462K	DO219191	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.2778
p.E685V	TCGA-UZ-A9PS	KIRP	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.1944
p.E685V	DO219709	KIRP	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.1944
p.E861D	DO50450	ESAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.2778
p.E861D	DO234343	ESAD	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.2778
p.I470V	DO233783	GACA	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.5965
p.T664R	DO228835	LICA	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.0556
p.L677M	DO229019	LICA	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation altering degron motif	0.5999
p.Q853K	DO229019	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation altering degron motif	0.5833
p.Q854K	DO229022	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation altering degron motif	0.5833
p.T680N	DO229022	LICA	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation altering degron motif	0.7055
p.P857T	DO229036	LICA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation altering degron motif	0.5919
p.S478R	DO229041	LICA	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1667
p.D481V	DO48703	LIRI	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.0833
p.D481V	DO230993	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.0833
p.D481V	DO224558	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.0833
p.P457L	DO220877	MELA	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.1389
p.P482S	DO222837	MELA	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation rewiring degron network	0.0556
p.H464P	DO27945	ORCA	ICGC	HPHATVIPD	DEG_SIAH_1	464:472	Mutation altering degron motif	0.6583
p.P866S	DO219873	SKCA	ICGC	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1389
p.A682T	SIDM00238	Ovarian Carcinoma	GDSC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.2778
p.A682T	ACH-000947	Ovarian Cancer	CCLE	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.2778
p.A682T	OVK-18	ovary	COSMIC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation rewiring degron network	0.2778
p.D674G	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation altering degron motif	0.7198
p.D674G	ACH-002275	Leukemia	CCLE	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation altering degron motif	0.7198
p.D674G	MN-60	haematopoietic and lymphoid tissue	COSMIC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation altering degron motif	0.7198
p.S675N	SIDM00217	Colorectal Carcinoma	GDSC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation altering degron motif	0.7069
p.S675N	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation altering degron motif	0.7069
p.S675N	SNU-1040	large intestine	COSMIC	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation altering degron motif	0.7069
p.K689R	ACH-000937	Leukemia	CCLE	DSGLDVT	DEG_SCF_TRCP1_1	674:680	Mutation substituting flanking lysine	0.1944
p.D865Y	ACH-000961	Endometrial/Uterine Cancer	CCLE	LQQTPPCS	DEG_SCF_FBW7_1	852:859	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC66

UniProt ID: Q68CR7

Entrez ID: 339977

Protein name: Leucine-rich repeat-containing protein 66

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC66 in