DegronMD

Uniprot ID: Q68CR7

Source protein: Leucine-rich repeat-containing protein 66

Source gene: LRRC66

Class: DEG_SCF_TRCP1_1

Location: 674:680

E3 ligase: BTRC

DEGRON score: 0.9963

ASA_SCORE: 74.5571

COIL: 0.9156

CONS_SCORE: 0.3272

DSS_SCORE: 0.5964

HELIX: 0.0379

FCONS_SCORE: 0.7356

RIG_SCORE: 0.7027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K684N	TCGA-D3-A2JL	SKCM	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	0.3333
p.K684N	DO47278	SKCM	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	0.3333
p.P670S	TCGA-EE-A2MJ	SKCM	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	0.2222
p.P670S	DO38099	SKCM	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	0.2222
p.P666L	TCGA-FS-A1ZW	SKCM	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	0.1111
p.P666L	DO37519	SKCM	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	0.1111
p.R672K	TCGA-GN-A266	SKCM	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	0.2778
p.R672K	DO37432	SKCM	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	0.2778
p.E685V	TCGA-UZ-A9PS	KIRP	TCGA	DSGLDVT	DEG_SCF_TRCP1_1	0.1944
p.E685V	DO219709	KIRP	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	0.1944
p.T664R	DO228835	LICA	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	0.0556
p.L677M	DO229019	LICA	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	0.5999
p.T680N	DO229022	LICA	ICGC	DSGLDVT	DEG_SCF_TRCP1_1	0.7055
p.A682T	SIDM00238	Ovarian Carcinoma	GDSC	DSGLDVT	DEG_SCF_TRCP1_1	0.2778
p.A682T	ACH-000947	Ovarian Cancer	CCLE	DSGLDVT	DEG_SCF_TRCP1_1	0.2778
p.A682T	OVK-18	ovary	COSMIC	DSGLDVT	DEG_SCF_TRCP1_1	0.2778
p.D674G	SIDM00438	B-Lymphoblastic Leukemia	GDSC	DSGLDVT	DEG_SCF_TRCP1_1	0.7198
p.D674G	ACH-002275	Leukemia	CCLE	DSGLDVT	DEG_SCF_TRCP1_1	0.7198
p.D674G	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	DSGLDVT	DEG_SCF_TRCP1_1	0.7198
p.S675N	SIDM00217	Colorectal Carcinoma	GDSC	DSGLDVT	DEG_SCF_TRCP1_1	0.7069
p.S675N	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGLDVT	DEG_SCF_TRCP1_1	0.7069
p.S675N	SNU-1040	large_intestine	COSMIC	DSGLDVT	DEG_SCF_TRCP1_1	0.7069
p.K689R	ACH-000937	Leukemia	CCLE	DSGLDVT	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CR7	Leucine-rich repeat-containing protein 66	DEG_SCF_TRCP1_1	674:680	DSGLDVT	BTRC	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons