DegronMD

Uniprot ID: Q68CR7

Source protein: Leucine-rich repeat-containing protein 66

Source gene: LRRC66

Class: DEG_SIAH_1

Location: 464:472

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.995

ASA_SCORE: 73.3333

COIL: 0.7466

CONS_SCORE: 0.3572

DSS_SCORE: 0.587

HELIX: 0.1064

FCONS_SCORE: 0.8962

RIG_SCORE: 0.746

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F458L	TCGA-60-2698	LUSC	TCGA	HPHATVIPD	DEG_SIAH_1	0.1667
p.F458L	TCGA-66-2783	LUSC	TCGA	HPHATVIPD	DEG_SIAH_1	0.1667
p.F458L	TCGA-CV-6961	HNSC	TCGA	HPHATVIPD	DEG_SIAH_1	0.1667
p.F458L	DO14566	HNSC	ICGC	HPHATVIPD	DEG_SIAH_1	0.1667
p.F458L	DO26469	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	0.1667
p.F458L	DO26452	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	0.1667
p.A467T	TCGA-AJ-A3OK	UCEC	TCGA	HPHATVIPD	DEG_SIAH_1	0.7139
p.A467T	TCGA-EO-A22R	UCEC	TCGA	HPHATVIPD	DEG_SIAH_1	0.7139
p.A467T	DO227657	COCA	ICGC	HPHATVIPD	DEG_SIAH_1	0.7139
p.A467T	DO43602	UCEC	ICGC	HPHATVIPD	DEG_SIAH_1	0.7139
p.A467T	DO42713	UCEC	ICGC	HPHATVIPD	DEG_SIAH_1	0.7139
p.A467S	TCGA-BR-6452	STAD	TCGA	HPHATVIPD	DEG_SIAH_1	0.7588
p.A467S	DO38404	STAD	ICGC	HPHATVIPD	DEG_SIAH_1	0.7588
p.G476E	TCGA-EE-A2A2	SKCM	TCGA	HPHATVIPD	DEG_SIAH_1	0.2222
p.G476E	DO37583	SKCM	ICGC	HPHATVIPD	DEG_SIAH_1	0.2222
p.R477T	TCGA-FW-A3R5	SKCM	TCGA	HPHATVIPD	DEG_SIAH_1	0.1944
p.R477T	DO37406	SKCM	ICGC	HPHATVIPD	DEG_SIAH_1	0.1944
p.P471S	TCGA-GN-A4U7	SKCM	TCGA	HPHATVIPD	DEG_SIAH_1	0.6752
p.P471S	DO222847	MELA	ICGC	HPHATVIPD	DEG_SIAH_1	0.6752
p.P471S	DO51258	SKCM	ICGC	HPHATVIPD	DEG_SIAH_1	0.6752
p.Q462H	TCGA-IB-7651	PAAD	TCGA	HPHATVIPD	DEG_SIAH_1	0.2778
p.Q462H	DO46657	PAAD	ICGC	HPHATVIPD	DEG_SIAH_1	0.2778
p.D481Y	TCGA-L3-A4E7	LUSC	TCGA	HPHATVIPD	DEG_SIAH_1	0.0833
p.D481Y	DO45458	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	0.0833
p.Q462K	TCGA-NC-A5HK	LUSC	TCGA	HPHATVIPD	DEG_SIAH_1	0.2778
p.Q462K	DO219191	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	0.2778
p.I470V	DO233783	GACA	ICGC	HPHATVIPD	DEG_SIAH_1	0.5965
p.S478R	DO229041	LICA	ICGC	HPHATVIPD	DEG_SIAH_1	0.1667
p.D481V	DO48703	LIRI	ICGC	HPHATVIPD	DEG_SIAH_1	0.0833
p.D481V	DO230993	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	0.0833
p.D481V	DO224558	LUSC	ICGC	HPHATVIPD	DEG_SIAH_1	0.0833
p.P457L	DO220877	MELA	ICGC	HPHATVIPD	DEG_SIAH_1	0.1389
p.P482S	DO222837	MELA	ICGC	HPHATVIPD	DEG_SIAH_1	0.0556
p.H464P	DO27945	ORCA	ICGC	HPHATVIPD	DEG_SIAH_1	0.6583

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HPHATVIPD

Degron related mutations and impact score

Drug responses associated with LRRC66 mutations

All proteins holding degron of HPHATVIPD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CR7	Leucine-rich repeat-containing protein 66	DEG_SIAH_1	464:472	HPHATVIPD	SIAH1,SIAH2,SIAH3	0.995	More...