DegronMD

Uniprot ID: Q9NZU0

Source protein: Leucine-rich repeat transmembrane protein FLRT3

Source gene: FLRT3

Class: DEG_SCF_TRCP1_1

Location: 638:644

E3 ligase: BTRC

DEGRON score: 0.7288

ASA_SCORE: 66.5571

COIL: 0.8336

CONS_SCORE: 0.5547

DSS_SCORE: 0.7483

HELIX: 0.1029

FCONS_SCORE: 0.9369

RIG_SCORE: 0.5374

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R634Q	TCGA-F5-6814	READ	TCGA	DSGIPDS	DEG_SCF_TRCP1_1	0.2222
p.R634Q	DO222884	COCA	ICGC	DSGIPDS	DEG_SCF_TRCP1_1	0.2222
p.R634Q	DO36556	READ	ICGC	DSGIPDS	DEG_SCF_TRCP1_1	0.2222
p.R634Q	ACH-001786	Colon/Colorectal Cancer	CCLE	DSGIPDS	DEG_SCF_TRCP1_1	0.2222
p.S628G	TCGA-HT-7481	LGG	TCGA	DSGIPDS	DEG_SCF_TRCP1_1	0.0556
p.S628G	DO22756	LGG	ICGC	DSGIPDS	DEG_SCF_TRCP1_1	0.0556
p.R637I	TCGA-RD-A7BS	STAD	TCGA	DSGIPDS	DEG_SCF_TRCP1_1	0.3056
p.R637I	DO50130	STAD	ICGC	DSGIPDS	DEG_SCF_TRCP1_1	0.3056
p.D643E	SIDM00360	Other Solid Cancers	GDSC	DSGIPDS	DEG_SCF_TRCP1_1	0.5647
p.D643E	ACH-000347	Pancreatic Cancer	CCLE	DSGIPDS	DEG_SCF_TRCP1_1	0.5647
p.D643E	QGP-1	pancreas	COSMIC	DSGIPDS	DEG_SCF_TRCP1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZU0	Leucine-rich repeat transmembrane protein FLRT3	DEG_SCF_TRCP1_1	638:644	DSGIPDS	BTRC	0.7288	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons