DegronMD - Q9NZU0(FLRT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D347V	TCGA-85-7699	LUSC	TCGA	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0556
p.D347V	DO26534	LUSC	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0556
p.T373P	TCGA-AP-A056	UCEC	TCGA	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0556
p.T373P	DO43971	UCEC	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0556
p.T373I	TCGA-BR-8487	STAD	TCGA	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0556
p.T373I	DO47867	STAD	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0556
p.T367N	TCGA-CA-6717	COAD	TCGA	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.2222
p.T367N	DO8264	COAD	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.2222
p.T363I	TCGA-D9-A3Z1	SKCM	TCGA	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation altering degron motif	0.7078
p.T363I	DO38105	SKCM	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation altering degron motif	0.7078
p.I364T	TCGA-D9-A4Z6	SKCM	TCGA	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.3056
p.I364T	DO47485	SKCM	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.3056
p.L348F	TCGA-EE-A2ML	SKCM	TCGA	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0833
p.L348F	DO222429	MELA	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0833
p.L348F	DO37408	SKCM	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0833
p.R634Q	TCGA-F5-6814	READ	TCGA	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation rewiring degron network	0.2222
p.R634Q	DO222884	COCA	ICGC	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation rewiring degron network	0.2222
p.R634Q	DO36556	READ	ICGC	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation rewiring degron network	0.2222
p.R634Q	ACH-001786	Colon/Colorectal Cancer	CCLE	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation rewiring degron network	0.2222
p.S628G	TCGA-HT-7481	LGG	TCGA	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation rewiring degron network	0.0556
p.S628G	DO22756	LGG	ICGC	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation rewiring degron network	0.0556
p.R637I	TCGA-RD-A7BS	STAD	TCGA	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation rewiring degron network	0.3056
p.R637I	DO50130	STAD	ICGC	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation rewiring degron network	0.3056
p.D357E	DO229041	LICA	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation altering degron motif	0.6758
p.L348V	DO45155	LIRI	ICGC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.0833
p.T367I	SIDM00789	Colorectal Carcinoma	GDSC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.2222
p.T367I	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.2222
p.T367I	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.2222
p.T367I	HCT-15	large intestine	COSMIC	DSGIVST	DEG_SCF_TRCP1_1	357:363	Mutation rewiring degron network	0.2222
p.D643E	SIDM00360	Other Solid Cancers	GDSC	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation altering degron motif	0.5647
p.D643E	ACH-000347	Pancreatic Cancer	CCLE	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation altering degron motif	0.5647
p.D643E	QGP-1	pancreas	COSMIC	DSGIPDS	DEG_SCF_TRCP1_1	638:644	Mutation altering degron motif	0.5647

Kaplan plot for FLRT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FLRT3

UniProt ID: Q9NZU0

Entrez ID: 23767

Protein name: Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FLRT3 in