DegronMD

Uniprot ID: Q9NZU0

Source protein: Leucine-rich repeat transmembrane protein FLRT3

Source gene: FLRT3

Class: DEG_SCF_TRCP1_1

Location: 357:363

E3 ligase: BTRC

DEGRON score: 0.7146

ASA_SCORE: 68.0714

COIL: 0.7679

CONS_SCORE: 0.5916

DSS_SCORE: 0.1464

HELIX: 0.0391

FCONS_SCORE: 0.951

RIG_SCORE: 0.8174

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D347V	TCGA-85-7699	LUSC	TCGA	DSGIVST	DEG_SCF_TRCP1_1	0.0556
p.D347V	DO26534	LUSC	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.0556
p.T373P	TCGA-AP-A056	UCEC	TCGA	DSGIVST	DEG_SCF_TRCP1_1	0.0556
p.T373P	DO43971	UCEC	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.0556
p.T373I	TCGA-BR-8487	STAD	TCGA	DSGIVST	DEG_SCF_TRCP1_1	0.0556
p.T373I	DO47867	STAD	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.0556
p.T367N	TCGA-CA-6717	COAD	TCGA	DSGIVST	DEG_SCF_TRCP1_1	0.2222
p.T367N	DO8264	COAD	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.2222
p.T363I	TCGA-D9-A3Z1	SKCM	TCGA	DSGIVST	DEG_SCF_TRCP1_1	0.7078
p.T363I	DO38105	SKCM	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.7078
p.I364T	TCGA-D9-A4Z6	SKCM	TCGA	DSGIVST	DEG_SCF_TRCP1_1	0.3056
p.I364T	DO47485	SKCM	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.3056
p.L348F	TCGA-EE-A2ML	SKCM	TCGA	DSGIVST	DEG_SCF_TRCP1_1	0.0833
p.L348F	DO222429	MELA	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.0833
p.L348F	DO37408	SKCM	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.0833
p.D357E	DO229041	LICA	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.6758
p.L348V	DO45155	LIRI	ICGC	DSGIVST	DEG_SCF_TRCP1_1	0.0833
p.T367I	SIDM00789	Colorectal Carcinoma	GDSC	DSGIVST	DEG_SCF_TRCP1_1	0.2222
p.T367I	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGIVST	DEG_SCF_TRCP1_1	0.2222
p.T367I	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGIVST	DEG_SCF_TRCP1_1	0.2222
p.T367I	HCT-15	large_intestine	COSMIC	DSGIVST	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZU0	Leucine-rich repeat transmembrane protein FLRT3	DEG_SCF_TRCP1_1	357:363	DSGIVST	BTRC	0.7146	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons