DegronMD

Uniprot ID: P50851

Source protein: Lipopolysaccharide-responsive and beige-like anchor protein

Source gene: LRBA

Class: DEG_SCF_TRCP1_1

Location: 1176:1181

E3 ligase: BTRC

DEGRON score: 0.9928

ASA_SCORE: 81.35

COIL: 0.7715

CONS_SCORE: 0.2443

DSS_SCORE: 0.6862

HELIX: 0.0865

FCONS_SCORE: 0.9958

RIG_SCORE: 0.6829

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1176Y	TCGA-AP-A056	UCEC	TCGA	DSGIQT	DEG_SCF_TRCP1_1	0.7325
p.D1176Y	DO43971	UCEC	ICGC	DSGIQT	DEG_SCF_TRCP1_1	0.7325
p.T1167A	SIDM00335	Endometrial Carcinoma	GDSC	DSGIQT	DEG_SCF_TRCP1_1	0.5278
p.T1167A	MFE-280	endometrium	COSMIC	DSGIQT	DEG_SCF_TRCP1_1	0.5278
p.T1183A	TCGA-55-6982	LUAD	TCGA	DSGIQT	DEG_SCF_TRCP1_1	0.2778
p.T1183A	DO26280	LUAD	ICGC	DSGIQT	DEG_SCF_TRCP1_1	0.2778
p.T1183R	TCGA-D1-A2G0	UCEC	TCGA	DSGIQT	DEG_SCF_TRCP1_1	0.2778
p.T1183R	DO43049	UCEC	ICGC	DSGIQT	DEG_SCF_TRCP1_1	0.2778
p.Q1172K	DO229323	BTCA	ICGC	DSGIQT	DEG_SCF_TRCP1_1	0.2222
p.S1185P	DO228627	GACA	ICGC	DSGIQT	DEG_SCF_TRCP1_1	0.2222
p.M1190I	TCGA-BR-4201	STAD	TCGA	DSGIQT	DEG_SCF_TRCP1_1	0.0833
p.M1190I	DO38707	STAD	ICGC	DSGIQT	DEG_SCF_TRCP1_1	0.0833

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50851	Lipopolysaccharide-responsive and beige-like anchor protein	DEG_SCF_TRCP1_1	1176:1181	DSGIQT	BTRC	0.9928	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons