DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGIQT
Uniprot ID:
P50851
Source protein:
Lipopolysaccharide-responsive and beige-like anchor protein
Source gene:
LRBA
Class:
DEG_SCF_TRCP1_1
Location:
1176:1181
E3 ligase:
BTRC
DEGRON score:
0.9928
ASA_SCORE:
81.35
COIL:
0.7715
CONS_SCORE:
0.2443
DSS_SCORE:
0.6862
HELIX:
0.0865
FCONS_SCORE:
0.9958
RIG_SCORE:
0.6829
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1183A
TCGA-55-6982
LUAD
TCGA
DSGIQT
DEG_SCF_TRCP1_1
0.2778
p.T1183A
DO26280
LUAD
ICGC
DSGIQT
DEG_SCF_TRCP1_1
0.2778
p.D1176Y
TCGA-AP-A056
UCEC
TCGA
DSGIQT
DEG_SCF_TRCP1_1
0.7325
p.D1176Y
DO43971
UCEC
ICGC
DSGIQT
DEG_SCF_TRCP1_1
0.7325
p.M1190I
TCGA-BR-4201
STAD
TCGA
DSGIQT
DEG_SCF_TRCP1_1
0.0833
p.M1190I
DO38707
STAD
ICGC
DSGIQT
DEG_SCF_TRCP1_1
0.0833
p.T1183R
TCGA-D1-A2G0
UCEC
TCGA
DSGIQT
DEG_SCF_TRCP1_1
0.2778
p.T1183R
DO43049
UCEC
ICGC
DSGIQT
DEG_SCF_TRCP1_1
0.2778
p.Q1172K
DO229323
BTCA
ICGC
DSGIQT
DEG_SCF_TRCP1_1
0.2222
p.S1185P
DO228627
GACA
ICGC
DSGIQT
DEG_SCF_TRCP1_1
0.2222
p.T1167A
SIDM00335
Endometrial Carcinoma
GDSC
DSGIQT
DEG_SCF_TRCP1_1
0.5278
p.T1167A
MFE-280
endometrium
COSMIC
DSGIQT
DEG_SCF_TRCP1_1
0.5278
Drug responses associated with LRBA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGIQT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P50851
Lipopolysaccharide-responsive and beige-like anchor protein
DEG_SCF_TRCP1_1
1176:1181
DSGIQT
BTRC
0.9928
More...