DegronMD - P50851(LRBA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1183A	TCGA-55-6982	LUAD	TCGA	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation rewiring degron network	0.2778
p.T1183A	DO26280	LUAD	ICGC	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation rewiring degron network	0.2778
p.D1176Y	TCGA-AP-A056	UCEC	TCGA	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation altering degron motif	0.7325
p.D1176Y	DO43971	UCEC	ICGC	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation altering degron motif	0.7325
p.M1190I	TCGA-BR-4201	STAD	TCGA	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation rewiring degron network	0.0833
p.M1190I	DO38707	STAD	ICGC	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation rewiring degron network	0.0833
p.T1183R	TCGA-D1-A2G0	UCEC	TCGA	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation rewiring degron network	0.2778
p.T1183R	DO43049	UCEC	ICGC	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation rewiring degron network	0.2778
p.Q1172K	DO229323	BTCA	ICGC	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation rewiring degron network	0.2222
p.S1185P	DO228627	GACA	ICGC	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation rewiring degron network	0.2222
p.A2V	DO229234	THCA	ICGC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.3056
p.G18R	SIDM00590	Oral Cavity Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.G18R	SIDM00585	Hepatocellular Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.G18R	SIDM00375	Head and Neck Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.G18R	SIDM00927	Small Cell Lung Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.G18R	SIDM00549	B-Lymphoblastic Leukemia	GDSC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.G18R	SIDM00380	Acute Myeloid Leukemia	GDSC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.G18R	SIDM01018	Hodgkin's Lymphoma	GDSC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.G18R	SIDM01660	Kidney Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation rewiring degron network	0.1389
p.T1167A	SIDM00335	Endometrial Carcinoma	GDSC	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation blocking phosphorylation signal	0.5278
p.T1167A	MFE-280	endometrium	COSMIC	DSGIQT	DEG_SCF_TRCP1_1	1176:1181	Mutation blocking phosphorylation signal	0.5278
p.S3N	NCI-H2122	lung	COSMIC	SEDNRVPSP	DEG_COP1_1	3:11	Mutation altering degron motif	0.818

Kaplan plot for LRBA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRBA

UniProt ID: P50851

Entrez ID: 987

Protein name: Lipopolysaccharide-responsive and beige-like anchor protein (Beige-like protein) (CDC4-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRBA in