DegronMD

Uniprot ID: P50851

Source protein: Lipopolysaccharide-responsive and beige-like anchor protein

Source gene: LRBA

Class: DEG_COP1_1

Location: 3:11

E3 ligase: COP1

DEGRON score: 0.9909

ASA_SCORE: 109.0333

COIL: 0.9663

CONS_SCORE: 0.2531

DSS_SCORE: 0.9598

HELIX: 0.0176

FCONS_SCORE: 0.9748

RIG_SCORE: 0.577

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2V	DO229234	THCA	ICGC	SEDNRVPSP	DEG_COP1_1	0.3056
p.G18R	SIDM00590	Oral Cavity Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	0.1389
p.G18R	SIDM00585	Hepatocellular Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	0.1389
p.G18R	SIDM00375	Head and Neck Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	0.1389
p.G18R	SIDM00927	Small Cell Lung Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	0.1389
p.G18R	SIDM00549	B-Lymphoblastic Leukemia	GDSC	SEDNRVPSP	DEG_COP1_1	0.1389
p.G18R	SIDM00380	Acute Myeloid Leukemia	GDSC	SEDNRVPSP	DEG_COP1_1	0.1389
p.G18R	SIDM01018	Hodgkin's Lymphoma	GDSC	SEDNRVPSP	DEG_COP1_1	0.1389
p.G18R	SIDM01660	Kidney Carcinoma	GDSC	SEDNRVPSP	DEG_COP1_1	0.1389
p.S3N	NCI-H2122	lung	COSMIC	SEDNRVPSP	DEG_COP1_1	0.818

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50851	Lipopolysaccharide-responsive and beige-like anchor protein	DEG_COP1_1	3:11	SEDNRVPSP	COP1	0.9909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons