DegronMD

Uniprot ID: Q63HQ0

Source protein: AP-1 complex-associated regulatory protein

Source gene: AP1AR

Class: DEG_SCF_TRCP1_1

Location: 289:295

E3 ligase: BTRC

DEGRON score: 0.84

ASA_SCORE: 87.5429

COIL: 0.8294

CONS_SCORE: 0.4438

DSS_SCORE: 0.6374

HELIX: 0.1451

FCONS_SCORE: 0.7248

RIG_SCORE: 0.6579

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D296G	TCGA-EY-A1GI	UCEC	TCGA	DSGIRHS	DEG_SCF_TRCP1_1	0.3056
p.T297I	SIDM00973	Melanoma	GDSC	DSGIRHS	DEG_SCF_TRCP1_1	0.2778
p.T297I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGIRHS	DEG_SCF_TRCP1_1	0.2778
p.T297I	SIDM00254	Neuroblastoma	GDSC	DSGIRHS	DEG_SCF_TRCP1_1	0.2778
p.L287P	SIDM00333	Endometrial Carcinoma	GDSC	DSGIRHS	DEG_SCF_TRCP1_1	0.2778
p.L287P	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGIRHS	DEG_SCF_TRCP1_1	0.2778
p.L287P	MFE-319	endometrium	COSMIC	DSGIRHS	DEG_SCF_TRCP1_1	0.2778
p.R302Q	TCGA-AP-A051	UCEC	TCGA	DSGIRHS	DEG_SCF_TRCP1_1	0.1389
p.R302Q	TCGA-D8-A1JG	BRCA	TCGA	DSGIRHS	DEG_SCF_TRCP1_1	0.1389
p.R302L	TCGA-D3-A1QA	SKCM	TCGA	DSGIRHS	DEG_SCF_TRCP1_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q63HQ0	AP-1 complex-associated regulatory protein	DEG_SCF_TRCP1_1	289:295	DSGIRHS	BTRC	0.84	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons