DegronMD - Q63HQ0(AP1AR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R302Q	TCGA-AP-A051	UCEC	TCGA	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.1389
p.R302Q	TCGA-D8-A1JG	BRCA	TCGA	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.1389
p.R169Q	TCGA-AP-A056	UCEC	TCGA	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.0556
p.R169Q	TCGA-FI-A2D5	UCEC	TCGA	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.0556
p.R302L	TCGA-D3-A1QA	SKCM	TCGA	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.1389
p.R172G	TCGA-DI-A1BU	UCEC	TCGA	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.1389
p.R172G	DO42023	UCEC	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.1389
p.D296G	TCGA-EY-A1GI	UCEC	TCGA	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.3056
p.R192C	DO13863	GBM	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.1389
p.R192C	DO43041	UCEC	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.1389
p.R192C	DO41331	UCEC	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.1389
p.S187I	DO229026	LICA	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation blocking phosphorylation signal	0.7222
p.S174L	DO222662	MELA	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation blocking phosphorylation signal	0.6389
p.N184H	DO51407	PRAD	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation altering degron motif	0.7423
p.P188Q	DO37715	SKCM	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.25
p.P188Q	DO51236	SKCM	ICGC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation rewiring degron network	0.25
p.T297I	SIDM00973	Melanoma	GDSC	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.2778
p.T297I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.2778
p.T297I	SIDM00254	Neuroblastoma	GDSC	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.2778
p.L287P	SIDM00333	Endometrial Carcinoma	GDSC	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.2778
p.L287P	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.2778
p.L287P	MFE-319	endometrium	COSMIC	DSGIRHS	DEG_SCF_TRCP1_1	289:295	Mutation rewiring degron network	0.2778
p.K193E	SIDM00542	Glioblastoma	GDSC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation substituting flanking lysine	0.2222
p.K193E	ACH-002227	Brain Cancer	CCLE	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation substituting flanking lysine	0.2222
p.K193E	D-392MG	central nervous system	COSMIC	VLTPNTE	DEG_SCF_FBW7_2	179:185	Mutation substituting flanking lysine	0.2222

Kaplan plot for AP1AR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AP1AR

UniProt ID: Q63HQ0

Entrez ID: 55435

Protein name: AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AP1AR in